The frequency of oral famotidine administration influences its effect on gastric pH in cats over time.
Administration, Oral
Animals
Anti-Ulcer Agents
/ administration & dosage
Cats
/ metabolism
Cross-Over Studies
Drug Administration Schedule
/ veterinary
Famotidine
/ administration & dosage
Female
Gastric Acid
/ metabolism
Gastric Acidity Determination
/ veterinary
Hydrogen-Ion Concentration
/ drug effects
Male
Random Allocation
H2RA
acid suppressant
feline
gastrin
tolerance
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
09
08
2018
accepted:
16
01
2019
pubmed:
13
2
2019
medline:
30
6
2019
entrez:
13
2
2019
Statut:
ppublish
Résumé
Famotidine is commonly administered to cats. Prolonged famotidine administration results in decreased efficacy in humans, dogs, and cows, but the long-term effects in cats are unknown. To compare the effect of 2 oral administration frequencies of famotidine, twice daily (Group 1) and twice daily every second day (Group 2), on intragastric pH and serum gastrin concentrations in cats. We hypothesized a diminished effect on intragastric pH would be observed over time in Group 1 but not Group 2. Sixteen healthy cats. Randomized, 2-factor repeated measures crossover design. Cats received 0.5-1.24 mg/kg (median, 0.87 mg/kg) famotidine twice daily or twice daily every second day for 14 consecutive days. Intragastric pH monitoring was used to record intragastric pH on treatment days 1-3 and 11-13. Mean pH and mean percentage time (MPT) intragastric pH was ≥3 and 4 were compared between and within treatment groups by analysis of variance. Significant treatment group by time interactions were observed for mean intragastric pH, MPT intragastric pH ≥3 and 4 (P = .009, P = .02, P = .005, respectively). Interaction post hoc tests identified significant decreases in mean intragastric pH (P = .001), MPT ≥3 (P = .001), and MPT ≥4 (P = .001) on day 13 compared to day 1 in Group 1 but not in Group 2. Oral famotidine administration results in a diminished effect on intragastric pH in healthy cats when given twice daily every day.
Sections du résumé
BACKGROUND
BACKGROUND
Famotidine is commonly administered to cats. Prolonged famotidine administration results in decreased efficacy in humans, dogs, and cows, but the long-term effects in cats are unknown.
OBJECTIVES
OBJECTIVE
To compare the effect of 2 oral administration frequencies of famotidine, twice daily (Group 1) and twice daily every second day (Group 2), on intragastric pH and serum gastrin concentrations in cats. We hypothesized a diminished effect on intragastric pH would be observed over time in Group 1 but not Group 2.
ANIMALS
METHODS
Sixteen healthy cats.
METHODS
METHODS
Randomized, 2-factor repeated measures crossover design. Cats received 0.5-1.24 mg/kg (median, 0.87 mg/kg) famotidine twice daily or twice daily every second day for 14 consecutive days. Intragastric pH monitoring was used to record intragastric pH on treatment days 1-3 and 11-13. Mean pH and mean percentage time (MPT) intragastric pH was ≥3 and 4 were compared between and within treatment groups by analysis of variance.
RESULTS
RESULTS
Significant treatment group by time interactions were observed for mean intragastric pH, MPT intragastric pH ≥3 and 4 (P = .009, P = .02, P = .005, respectively). Interaction post hoc tests identified significant decreases in mean intragastric pH (P = .001), MPT ≥3 (P = .001), and MPT ≥4 (P = .001) on day 13 compared to day 1 in Group 1 but not in Group 2.
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
Oral famotidine administration results in a diminished effect on intragastric pH in healthy cats when given twice daily every day.
Identifiants
pubmed: 30746763
doi: 10.1111/jvim.15430
pmc: PMC6430900
doi:
Substances chimiques
Anti-Ulcer Agents
0
Famotidine
5QZO15J2Z8
Types de publication
Clinical Trial, Veterinary
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
544-550Subventions
Organisme : Winn Feline Foundation
ID : Tolbert W17-017
Organisme : Companion Animal Research
Informations de copyright
© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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