Oxanosine Monophosphate Is a Covalent Inhibitor of Inosine 5'-Monophosphate Dehydrogenase.
Journal
Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448
Informations de publication
Date de publication:
18 03 2019
18 03 2019
Historique:
pubmed:
13
2
2019
medline:
14
2
2020
entrez:
13
2
2019
Statut:
ppublish
Résumé
Reactive nitrogen species (RNS) are produced during infection and inflammation, and the effects of these agents on proteins, DNA, and lipids are well recognized. In contrast, the effects of RNS damaged metabolites are less appreciated. 5-Amino-3-β-(d-ribofuranosyl)-3 H-imidazo-[4,5- d][1,3]oxazine-7-one (oxanosine) and its nucleotides are products of guanosine nitrosation. Here we demonstrate that oxanosine monophosphate (OxMP) is a potent reversible competitive inhibitor of IMPDH. The value of K
Identifiants
pubmed: 30746940
doi: 10.1021/acs.chemrestox.8b00342
pmc: PMC6467267
mid: NIHMS1016642
doi:
Substances chimiques
Enzyme Inhibitors
0
Phosphates
0
Ribonucleosides
0
oxanosine
80394-72-5
IMP Dehydrogenase
EC 1.1.1.205
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
456-466Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201200026C
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201700060C
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM054403
Pays : United States
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