Epigenetic modification in 4T1 mouse breast cancer model by artificial light at night and melatonin - the role of DNA-methyltransferase.

Animals Breast Neoplasms / metabolism Circadian Rhythm / physiology DNA / metabolism DNA Methylation / genetics Epigenesis, Genetic / genetics Humans Light Lung Neoplasms / metabolism Melatonin / metabolism Methyltransferases / metabolism Mice
Cosinor analysis DNA methyltransferases global DNA methylation melatonin splenomegaly tissue-specific

Journal

Chronobiology international
ISSN: 1525-6073
Titre abrégé: Chronobiol Int
Pays: England
ID NLM: 8501362

Informations de publication

Date de publication:
05 2019
Historique:
pubmed: 13 2 2019
medline: 22 8 2020
entrez: 13 2 2019
Statut: ppublish

Résumé

Currently, one of the most disputed hypotheses regarding breast cancer (BC) development is exposure to short wavelength artificial light at night (ALAN) as multiple studies suggest a possible link between them. This link is suggested to be mediated by nocturnal melatonin suppression that plays an integral role in circadian regulations including cell division. The objective of the research was to evaluate effects of 1 × 30 min/midnight ALAN (134 µ Wcm

Identifiants

DOI: 10.1080/07420528.2019.1574265 PMID: 30746962
pubmed: 30746962
doi: 10.1080/07420528.2019.1574265
doi:

Substances chimiques

DNA 9007-49-2
Methyltransferases EC 2.1.1.-
Melatonin JL5DK93RCL

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

629-643

Auteurs

Sahar Agbaria (S)

a Department of Human Biology , University of Haifa , Haifa , Israel.
ORCID: 0000-0002-7016-4540

Abraham Haim (A)

b The Israeli Center for Interdisciplinary Research in Chronobiology , University of Haifa , Haifa , Israel.
ORCID: 0000-0002-0284-8035

Fuad Fares (F)

a Department of Human Biology , University of Haifa , Haifa , Israel.
c Department of Molecular Genetics , Carmel Medical Center , Haifa , Israel.
ORCID: 0000-0002-4408-8847

Abed E Zubidat (AE)

b The Israeli Center for Interdisciplinary Research in Chronobiology , University of Haifa , Haifa , Israel.
ORCID: 0000-0002-5649-1086

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Epigenetic modification in 4T1 mouse breast...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Epigenetic modification in 4T1 mouse breast...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Rythme circadien › Epigenetic modification in 4T1 mouse breast...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Epigenetic modification in 4T1 mouse breast...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Epigenetic modification in 4T1 mouse breast...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenetic modification in 4T1 mouse breast...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenetic modification in 4T1 mouse breast...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Epigenetic modification in 4T1 mouse breast...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Epigenetic modification in 4T1 mouse breast...
questionsmedicales.fr › Mélatonine › Epigenetic modification in 4T1 mouse breast...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Epigenetic modification in 4T1 mouse breast...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Epigenetic modification in 4T1 mouse breast...