Repositioning Flubendazole for Spinal Cord Injury.
b cell-directed therapy
cyclin b1
flubendazole
mild microtubule destabilization
traumatic SCI
Journal
Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626
Informations de publication
Date de publication:
15 09 2019
15 09 2019
Historique:
pubmed:
13
2
2019
medline:
27
10
2020
entrez:
13
2
2019
Statut:
ppublish
Résumé
We previously reported the serendipitous observation that fenbendazole, a benzimidazole anthelmintic, improved functional and pathological outcomes following thoracic spinal cord contusion injury in mice when administered pre-injury. Fenbendazole is widely used in veterinary medicine. However, it is not approved for human use and it was uncertain if only post-injury administration would offer similar benefits. In the present study we evaluated post-injury administration of a closely related, human anthelmintic drug, flubendazole, using a rat spinal cord contusion injury model. Flubendazole, administered i.p. 5 or 10 mg/kg day, beginning 3 h post-injury and daily thereafter for 2 or 4 weeks, resulted in improved locomotor function after contusion spinal cord injury (SCI) compared with vehicle-treated controls. Histological analysis of spinal cord sections showed that such treatment with flubendazole also reduced lesion volume and improved total tissue sparing, white matter sparing, and gray matter sparing. Flubendazole inhibited the activation of glial fibrillary acidic protein (GFAP); suppressed cyclin B1 expression and Bruton tyrosine kinase activation, markers of B cell activation/proliferation and inflammation; and reduced B cell autoimmune response. Together, these results suggest the use of the benzimidazole anthelmintic flubendazole as a potential therapeutic for SCI.
Identifiants
pubmed: 30747048
doi: 10.1089/neu.2018.6160
pmc: PMC6727476
doi:
Substances chimiques
Antinematodal Agents
0
Neuroprotective Agents
0
Mebendazole
81G6I5V05I
flubendazole
R8M46911LR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2618-2630Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000117
Pays : United States
Commentaires et corrections
Type : ErratumIn
Références
J Neurotrauma. 2000 Jan;17(1):1-17
pubmed: 10674754
J Neurotrauma. 2001 May;18(5):513-22
pubmed: 11393254
Int J Parasitol. 2001 Apr;31(4):336-45
pubmed: 11400692
J Neurotrauma. 2003 Feb;20(2):179-93
pubmed: 12675971
Nat Rev Cancer. 2004 Apr;4(4):253-65
pubmed: 15057285
Parasitol Today. 1990 Apr;6(4):112-5
pubmed: 15463312
Parasitol Today. 1990 Apr;6(4):115-24
pubmed: 15463313
Curr Med Chem Anticancer Agents. 2005 Jan;5(1):65-71
pubmed: 15720262
J Neurotrauma. 2005 Apr;22(4):415-28
pubmed: 15853460
Brain Res Mol Brain Res. 2005 Aug 18;138(2):244-55
pubmed: 15922485
N Z Vet J. 1994 Dec;42(6):216-20
pubmed: 16031786
Mol Reprod Dev. 2005 Nov;72(3):336-45
pubmed: 16097011
Parasitology. 2006 Mar;132(Pt 3):301-13
pubmed: 16332285
J Neurochem. 2006 Nov;99(4):1073-87
pubmed: 17081140
N Z Med J. 2007 Jan 26;120(1248):U2402
pubmed: 17277818
Neurochem Res. 2007 Dec;32(12):2046-53
pubmed: 17476592
J Am Assoc Lab Anim Sci. 2007 Nov;46(6):8-15
pubmed: 17994667
J Allergy Clin Immunol. 2008 Jan;121(1):13-21; quiz 22-3
pubmed: 18206502
Immunol Rev. 2009 Mar;228(1):58-73
pubmed: 19290921
J Am Assoc Lab Anim Sci. 2009 May;48(3):251-7
pubmed: 19476712
J Clin Invest. 2009 Oct;119(10):2990-9
pubmed: 19770513
J Clin Invest. 2009 Oct;119(10):2881-4
pubmed: 19770517
J Neurochem. 2010 Apr;113(1):131-42
pubmed: 20067580
Pharmacol Ther. 2010 Mar;125(3):464-75
pubmed: 20097226
PLoS One. 2010 Feb 11;5(2):e9165
pubmed: 20161797
Exp Neurol. 2010 Jul;224(1):178-87
pubmed: 20302862
Cell. 2010 Mar 19;140(6):871-82
pubmed: 20303877
Blood. 2010 Jun 10;115(23):4824-33
pubmed: 20348394
J Vet Pharmacol Ther. 2009 Dec;32(6):606-12
pubmed: 20444016
Lab Anim. 2010 Jul;44(3):271-3
pubmed: 20457828
J Neurotrauma. 2011 Aug;28(8):1525-43
pubmed: 20507235
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80
pubmed: 20615965
Trends Immunol. 2010 Sep;31(9):332-8
pubmed: 20691635
Eur J Intern Med. 2010 Dec;21(6):503-8
pubmed: 21111934
Science. 2011 Feb 18;331(6019):928-31
pubmed: 21273450
Neurotherapeutics. 2011 Apr;8(2):221-8
pubmed: 21373950
J Neurosci. 2011 Aug 24;31(34):12118-28
pubmed: 21865454
J Neuroinflammation. 2012 Feb 27;9:40
pubmed: 22369693
Mol Neurobiol. 2012 Oct;46(2):251-64
pubmed: 22684804
J Neuroinflammation. 2012 Jul 11;9:169
pubmed: 22784881
J Med Chem. 2012 Nov 8;55(21):8979-96
pubmed: 23020671
Int Rev Neurobiol. 2012;106:127-52
pubmed: 23211462
Anticancer Res. 2013 Feb;33(2):355-62
pubmed: 23393324
J Neurotrauma. 2013 Mar 15;30(6):441-52
pubmed: 23517137
Int J Cancer. 2013 Nov 15;133(10):2341-50
pubmed: 23640782
Anticancer Drugs. 2013 Oct;24(9):911-9
pubmed: 23884106
Diabetes Obes Metab. 2013 Sep;15 Suppl 3:10-8
pubmed: 24003916
Neuroscience. 2014 Jan 3;256:163-9
pubmed: 24183965
J Neurosci. 1989 Dec;9(12):4416-29
pubmed: 2480402
PLoS Negl Trop Dis. 2014 May 29;8(5):e2838
pubmed: 24874646
J Neurotrauma. 2014 Nov 1;31(21):1753-66
pubmed: 24934600
Exp Neurol. 2014 Nov;261:97-108
pubmed: 24999028
Clin Ther. 2014 Oct 1;36(10):1465-79
pubmed: 25151572
Sci Rep. 2015 Feb 03;5:8202
pubmed: 25644037
Oncotarget. 2015 Mar 20;6(8):6326-40
pubmed: 25811972
Atherosclerosis. 2015 Jun;240(2):497-509
pubmed: 25917947
J Neurosci. 2015 Jun 24;35(25):9287-301
pubmed: 26109654
Ther Clin Risk Manag. 2015 Jun 23;11:979-90
pubmed: 26150724
Semin Arthritis Rheum. 2015 Dec;45(3):341-50
pubmed: 26228647
J Am Heart Assoc. 2015 Aug 24;4(8):e002128
pubmed: 26304941
Biomed Pharmacother. 2016 Mar;78:308-321
pubmed: 26898456
J Basic Clin Pharm. 2016 Mar;7(2):27-31
pubmed: 27057123
Int J Parasitol Drugs Drug Resist. 2015 Dec;5(3):178-84
pubmed: 27120064
Methods Mol Biol. 2016;1413:403-21
pubmed: 27193863
Neurotherapeutics. 2016 Oct;13(4):880-894
pubmed: 27215219
J Neurotrauma. 2017 Mar 15;34(6):1209-1226
pubmed: 27775474
Exp Ther Med. 2017 Feb;13(2):595-603
pubmed: 28352336
Biochim Biophys Acta Gen Subj. 2017 Jul;1861(7):1833-1843
pubmed: 28366502
Acta Medica (Hradec Kralove). 2017;60(1):5-11
pubmed: 28399389
Materials (Basel). 2017 May 24;10(6):null
pubmed: 28772932
Cell Death Discov. 2018 Feb 14;4:18
pubmed: 29531815
Biochem Biophys Res Commun. 2018 Sep 18;503(4):2778-2783
pubmed: 30103945
J Neurotrauma. 2019 Jun 15;36(12):1974-1984
pubmed: 30489213
Am J Trop Med Hyg. 1984 Jul;33(4):627-31
pubmed: 6476207
Arch Int Pharmacodyn Ther. 1982 Apr;256(2):180-91
pubmed: 7103610
Biochim Biophys Acta. 1978 Dec 18;544(3):605-14
pubmed: 728472
Biochim Biophys Acta. 1980 Jun 19;630(2):271-8
pubmed: 7388055
Exp Neurol. 1996 Jun;139(2):244-56
pubmed: 8654527