Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor.
biochemistry
chemical biology
cone snail
diabetes
hypoglycemic shock
insulin
prey capture
venom
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
12 02 2019
12 02 2019
Historique:
received:
30
08
2018
accepted:
30
12
2018
entrez:
13
2
2019
pubmed:
13
2
2019
medline:
27
3
2020
Statut:
epublish
Résumé
The fish-hunting marine cone snail Insulin is a hormone critical for maintaining healthy blood sugar levels in humans. When the insulin system becomes faulty, blood sugar levels become too high, which can lead to diabetes. At the moment, the only effective treatment for one of the major types of diabetes are daily insulin injections. However, designing fast-acting insulin drugs has remained a challenge. Insulin molecules form clusters (so-called hexamers) that first have to dissolve in the body to activate the insulin receptor, which plays a key role in regulating the blood sugar levels throughout the body. This can take time and can therefore delay the blood-sugar control. In 2015, researchers discovered that the fish-hunting cone snail
Autres résumés
Type: plain-language-summary
(eng)
Insulin is a hormone critical for maintaining healthy blood sugar levels in humans. When the insulin system becomes faulty, blood sugar levels become too high, which can lead to diabetes. At the moment, the only effective treatment for one of the major types of diabetes are daily insulin injections. However, designing fast-acting insulin drugs has remained a challenge. Insulin molecules form clusters (so-called hexamers) that first have to dissolve in the body to activate the insulin receptor, which plays a key role in regulating the blood sugar levels throughout the body. This can take time and can therefore delay the blood-sugar control. In 2015, researchers discovered that the fish-hunting cone snail
Identifiants
pubmed: 30747102
doi: 10.7554/eLife.41574
pii: 41574
pmc: PMC6372279
doi:
pii:
Substances chimiques
Antigens, CD
0
Insulin
0
Mollusk Venoms
0
Poisons
0
INSR protein, human
EC 2.7.10.1
Receptor, Insulin
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK120430
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM122869
Pays : United States
Organisme : NIGMS NIH HHS
ID : 1RO1GM122869
Pays : United States
Organisme : Juvenile Diabetes Research Foundation United States of America
ID : 1-INO-2017-441-A-N
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019, Ahorukomeye et al.
Déclaration de conflit d'intérêts
PA, MD, MW, PF, NS, AS, BO, HS No competing interests declared, JG, SK, SR, BS, BF, DH author of the following patent application: WO2016172269A3 entitled "Insulin analogs having shortened B chain peptides and associated methods".
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