Extensive transmission of microbes along the gastrointestinal tract.
colorectal cancer
computational biology
gastrointestinal tract
human
infectious disease
metagenomics
microbiology
microbiome
rheumatoid arthritis
systems biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
12 02 2019
12 02 2019
Historique:
received:
09
10
2018
accepted:
03
02
2019
pubmed:
13
2
2019
medline:
27
3
2020
entrez:
13
2
2019
Statut:
epublish
Résumé
The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral species to the intestine is considered a rare aberrant event, and a hallmark of disease. By studying salivary and fecal microbial strain populations of 310 species in 470 individuals from five countries, we found that transmission to, and subsequent colonization of, the large intestine by oral microbes is common and extensive among healthy individuals. We found evidence for a vast majority of oral species to be transferable, with increased levels of transmission in colorectal cancer and rheumatoid arthritis patients and, more generally, for species described as opportunistic pathogens. This establishes the oral cavity as an endogenous reservoir for gut microbial strains, and oral-fecal transmission as an important process that shapes the gastrointestinal microbiome in health and disease.
Identifiants
pubmed: 30747106
doi: 10.7554/eLife.42693
pii: 42693
pmc: PMC6424576
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : H2020 European Research Council
ID : ERC-AdG-669830
Pays : International
Organisme : European Research Council
ID : 669830
Pays : International
Organisme : H2020 Marie Skłodowska-Curie Actions
ID : 661019
Pays : International
Organisme : German Network for Bioinformatics Infrastructure
ID : de.NBI #031A537B
Pays : International
Organisme : Fonds National de la Recherche Luxembourg
ID : CORE/15/BM/10404093
Pays : International
Organisme : German Network Bioinformatics
ID : de.NBI #031A537B
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019, Schmidt et al.
Déclaration de conflit d'intérêts
TS, MH, LC, SL, PC, AV, JW, OM, RA, EB, Cd, IS, AH, SS, GZ, PW, PB No competing interests declared
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