Metabolism and excretion of (

Adolescent Adult Animals Carbon Radioisotopes / administration & dosage Cytochrome P-450 Enzyme System / genetics Feces / chemistry Humans Imidazoles / metabolism Inactivation, Metabolic Macaca fascicularis Male Middle Aged Nicotinic Acids / metabolism Recombinant Proteins / genetics Young Adult
CYP Glucokinase MIST activator disproportionate human mass balance metabolite monkey radiolabel safety

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
Dec 2019
Historique:
pubmed: 13 2 2019
medline: 9 4 2020
entrez: 13 2 2019
Statut: ppublish

Résumé

1. The absorption, metabolism, and excretion of a single oral 450-mg dose of [

Identifiants

DOI: 10.1080/00498254.2019.1581960 PMID: 30747552
pubmed: 30747552
doi: 10.1080/00498254.2019.1581960
doi:

Substances chimiques

Carbon Radioisotopes 0
Imidazoles 0
Nicotinic Acids 0
Recombinant Proteins 0
Carbon-14 7V68J5677O
Cytochrome P-450 Enzyme System 9035-51-2
6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid AJ212MS2O2

Types de publication

Clinical Trial Journal Article Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Pagination

1447-1457

Auteurs

Raman Sharma (R)

Medicine Design Pfizer Worldwide Research and Development , Groton , CT , USA.

Arthur Bergman (A)

Clinical Pharmacology/Pharmacometrics Pfizer Worldwide Research and Development , Groton , CT , USA.

John Litchfield (J)

Medicine Design Pfizer Worldwide Research and Development , Cambridge , MA , USA.

Karen Atkinson (K)

Medicine Design Pfizer Worldwide Research and Development , Groton , CT , USA.

David J Kazierad (DJ)

Clinical Sciences Pfizer Worldwide Research and Development , Cambridge , MA , USA.

Amit S Kalgutkar (AS)

Medicine Design Pfizer Worldwide Research and Development , Cambridge , MA , USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Metabolism and excretion of (
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Metabolism and excretion of (
questionsmedicales.fr › Eucaryotes › Animaux › Metabolism and excretion of (
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du carbone › Metabolism and excretion of (
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Metabolism and excretion of (
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › Metabolism and excretion of (
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolism and excretion of (
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Metabolism and excretion of (
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biotransformation › Inactivation métabolique › Metabolism and excretion of (
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca fascicularis › Metabolism and excretion of (
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Metabolism and excretion of (
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides nicotiniques › Metabolism and excretion of (
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Metabolism and excretion of (
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Metabolism and excretion of (