UTX Mutations in Human Cancer.

Animals DNA-Binding Proteins / genetics Demethylation Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Histone Demethylases / genetics Histone-Lysine N-Methyltransferase Histones / metabolism Humans Mutation Neoplasms / enzymology Phenotype Signal Transduction Tumor Suppressor Proteins / genetics
UTX cancer chromatin gene expression transcription

Journal

Cancer cell
ISSN: 1878-3686
Titre abrégé: Cancer Cell
Pays: United States
ID NLM: 101130617

Informations de publication

Date de publication:
11 02 2019
Historique:
received: 07 09 2018
revised: 10 11 2018
accepted: 02 01 2019
entrez: 13 2 2019
pubmed: 13 2 2019
medline: 18 12 2019
Statut: ppublish

Résumé

Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX, encoded by KDM6A) is a histone demethylase that targets di- and tri-methylated histone H3 lysine 27 (H3K27). UTX function has been linked to homeotic gene expression, embryonic development, and cellular reprogramming. UTX and its protein interactors within the COMPASS family, including the MLL3 and MLL4 lysine methyltransferases, are frequently mutated in multiple human cancers; however, the molecular basis of how these mutations contribute to oncogenesis remains unclear. Here, we discuss catalytic-dependent and -independent functions of UTX and its partners MLL3 and MLL4 as part of the COMPASS family during development and in oncogenesis.

Identifiants

DOI: 10.1016/j.ccell.2019.01.001 PMID: 30753822 PMC: PMC6589339
pubmed: 30753822
pii: S1535-6108(19)30001-7
doi: 10.1016/j.ccell.2019.01.001
pmc: PMC6589339
mid: NIHMS1036234
pii:
doi:

Substances chimiques

DNA-Binding Proteins 0
Histones 0
KMT2C protein, human 0
Tumor Suppressor Proteins 0
Histone Demethylases EC 1.14.11.-
KDM6A protein, human EC 1.14.11.-
Histone-Lysine N-Methyltransferase EC 2.1.1.43
MLL4 protein, human EC 2.1.1.43

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

168-176

Subventions

Organisme : NCI NIH HHS
ID : R35 CA197569
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA070085
Pays : United States

Informations de copyright

Copyright © 2019. Published by Elsevier Inc.

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Auteurs

Lu Wang (L)

Simpson Querrey Center for Epigenetics, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Searle 6-512, 320 E. Superior St., Chicago, IL 60611, USA.

Ali Shilatifard (A)

Simpson Querrey Center for Epigenetics, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Searle 6-512, 320 E. Superior St., Chicago, IL 60611, USA. Electronic address: ash@northwestern.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › UTX Mutations in Human Cancer.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › UTX Mutations in Human Cancer.
questionsmedicales.fr › Métabolisme › Désalkylation › Déméthylation › UTX Mutations in Human Cancer.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › UTX Mutations in Human Cancer.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › UTX Mutations in Human Cancer.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH group donors › Oxidoreductases, (N-demethylating) › Histone Demethylases › UTX Mutations in Human Cancer.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Protein Methyltransferases › Histone méthyltransférases › Histone-lysine N-methyltransferase › UTX Mutations in Human Cancer.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › UTX Mutations in Human Cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › UTX Mutations in Human Cancer.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › UTX Mutations in Human Cancer.
questionsmedicales.fr › Tumeurs › UTX Mutations in Human Cancer.
questionsmedicales.fr › Phénomènes génétiques › Phénotype › UTX Mutations in Human Cancer.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › UTX Mutations in Human Cancer.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › UTX Mutations in Human Cancer.