The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca

Benzylamines / metabolism Calcium / metabolism Calcium Signaling Calcium-Calmodulin-Dependent Protein Kinase Type 2 / antagonists & inhibitors Calmodulin / metabolism Calorimetry Humans Phosphorylation Sulfonamides / metabolism Surface Plasmon Resonance
CaMKII KN-92 KN-93 calmidazolium calmodulin

Journal

Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R

Informations de publication

Date de publication:
29 03 2019
Historique:
received: 20 09 2018
revised: 14 12 2018
accepted: 04 02 2019
pubmed: 13 2 2019
medline: 3 4 2020
entrez: 13 2 2019
Statut: ppublish

Résumé

Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. CaMKII is activated by calcium-bound calmodulin (Ca

Identifiants

DOI: 10.1016/j.jmb.2019.02.001 PMID: 30753871
pubmed: 30753871
pii: S0022-2836(18)31104-5
doi: 10.1016/j.jmb.2019.02.001
pii:
doi:

Substances chimiques

Benzylamines 0
Calmodulin 0
Sulfonamides 0
KN 93 139298-40-1
Calcium-Calmodulin-Dependent Protein Kinase Type 2 EC 2.7.11.17
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1440-1459

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Melanie H Wong (MH)

Gilead Sciences Inc, 333 Lakeside Drive, Foster City, CA 94404, USA.

Alexandra B Samal (AB)

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Mike Lee (M)

Gilead Sciences Inc, 333 Lakeside Drive, Foster City, CA 94404, USA.

Jiri Vlach (J)

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Nikolai Novikov (N)

Gilead Sciences Inc, 333 Lakeside Drive, Foster City, CA 94404, USA.

Anita Niedziela-Majka (A)

Gilead Sciences Inc, 333 Lakeside Drive, Foster City, CA 94404, USA.

Joy Y Feng (JY)

Gilead Sciences Inc, 333 Lakeside Drive, Foster City, CA 94404, USA.

Dmitry O Koltun (DO)

Gilead Sciences Inc, 333 Lakeside Drive, Foster City, CA 94404, USA.

Katherine M Brendza (KM)

Gilead Sciences Inc, 333 Lakeside Drive, Foster City, CA 94404, USA.

Hyock Joo Kwon (HJ)

Gilead Sciences Inc, 333 Lakeside Drive, Foster City, CA 94404, USA.

Brian E Schultz (BE)

Gilead Sciences Inc, 333 Lakeside Drive, Foster City, CA 94404, USA.

Roman Sakowicz (R)

Gilead Sciences Inc, 333 Lakeside Drive, Foster City, CA 94404, USA.

Jamil S Saad (JS)

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address: saad@uab.edu.

Giuseppe A Papalia (GA)

Gilead Sciences Inc, 333 Lakeside Drive, Foster City, CA 94404, USA. Electronic address: jpapalia@gilead.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzyliques › Benzylamines › The KN-93 Molecule Inhibits...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › The KN-93 Molecule Inhibits...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › The KN-93 Molecule Inhibits...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Calcium-Calmodulin-Dependent Protein Kinases › Calcium-Calmodulin-Dependent Protein Kinase Type 2 › The KN-93 Molecule Inhibits...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines intracellulaires sensibles au calcium › Calmoduline › The KN-93 Molecule Inhibits...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Calorimétrie › The KN-93 Molecule Inhibits...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The KN-93 Molecule Inhibits...
questionsmedicales.fr › Métabolisme › Phosphorylation › The KN-93 Molecule Inhibits...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › The KN-93 Molecule Inhibits...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Résonance plasmonique de surface › The KN-93 Molecule Inhibits...