Epilepsy Gene Therapy Using an Engineered Potassium Channel.
EEG
epilepsy
gene therapy
lentivirus
potassium channel
seizure detection
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
17 04 2019
17 04 2019
Historique:
received:
07
05
2018
revised:
24
12
2018
accepted:
21
01
2019
pubmed:
14
2
2019
medline:
9
6
2020
entrez:
14
2
2019
Statut:
ppublish
Résumé
Refractory focal epilepsy is a devastating disease for which there is frequently no effective treatment. Gene therapy represents a promising alternative, but treating epilepsy in this way involves irreversible changes to brain tissue, so vector design must be carefully optimized to guarantee safety without compromising efficacy. We set out to develop an epilepsy gene therapy vector optimized for clinical translation. The gene encoding the voltage-gated potassium channel Kv1.1,
Identifiants
pubmed: 30755487
pii: JNEUROSCI.1143-18.2019
doi: 10.1523/JNEUROSCI.1143-18.2019
pmc: PMC6468110
doi:
Substances chimiques
Kv1.1 Potassium Channel
147173-20-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3159-3169Subventions
Organisme : Medical Research Council
ID : G0802158
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0801316
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L01095X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R025134/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N026101/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209807/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : G116/147
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Snowball et al.
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