The induced decrease in TLR2 and TLR4 by cerebrolysin in the alcoholic liver of rats.

Toll-like receptors (TLRs) are innate immunity receptors, which have an important role in modulating inflammation in disease. Cerebrolysin is a biotechnologically prepared peptide that stimulates neurotrophic regulation in the central nervous system. The aim of the present study was to investigate the effect of experimenting cerebrolysin on TLR2 and TLR4 in alcoholic liver disease (ALD). TLR2 and TLR4 expressions were determined using real-time polymerase chain reaction in rats, which have used alcohol and they were separated into five groups. The results of the present study showed that in mild dose of cerebrolysin, the expression of TLR2 and TLR4 was decreased significantly than other groups. Also, the results of the western blot analysis proved the same. The present study demonstrated that the anti-inflammatory effect of cerebrolysin can decrease the TLR2 and TLR4 expressions through downregulating nuclear factor-κB pathway in the ALD disease.

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