Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development.
Animals
Calcium-Binding Proteins
/ genetics
Cell Lineage
/ genetics
Galectin 3
/ genetics
Gene Expression Regulation, Developmental
Kidney
/ growth & development
Lectins, C-Type
/ genetics
Macrophages
/ metabolism
Mannose Receptor
Mannose-Binding Lectins
/ genetics
Mice
Nephrons
/ growth & development
Organogenesis
/ genetics
Receptors, Cell Surface
/ genetics
Receptors, G-Protein-Coupled
/ genetics
Stem Cells
/ metabolism
blood vessel
cell migration
developmental biology
human
morphogenesis
mouse
nephron
phagocytosis
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
13 02 2019
13 02 2019
Historique:
received:
31
10
2018
accepted:
29
01
2019
entrez:
14
2
2019
pubmed:
14
2
2019
medline:
4
4
2020
Statut:
epublish
Résumé
The origins and functions of kidney macrophages in the adult have been explored, but their roles during development remain largely unknown. Here we characterise macrophage arrival, localisation, heterogeneity, and functions during kidney organogenesis. Using genetic approaches to ablate macrophages, we identify a role for macrophages in nephron progenitor cell clearance as mouse kidney development begins. Throughout renal organogenesis, most kidney macrophages are perivascular and express F4/80 and CD206. These macrophages are enriched for mRNAs linked to developmental processes, such as blood vessel morphogenesis. Using antibody-mediated macrophage-depletion, we show macrophages support vascular anastomoses in cultured kidney explants. We also characterise a subpopulation of galectin-3
Identifiants
pubmed: 30758286
doi: 10.7554/eLife.43271
pii: 43271
pmc: PMC6374076
doi:
pii:
Substances chimiques
Adgre1 protein, mouse
0
Calcium-Binding Proteins
0
Galectin 3
0
Lectins, C-Type
0
Lgals3 protein, mouse
0
Mannose Receptor
0
Mannose-Binding Lectins
0
Receptors, Cell Surface
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/K501293/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P013732/1
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019, Munro et al.
Déclaration de conflit d'intérêts
DM, YW, JT, CV, ZL, CP, ED, TK, PH, JD No competing interests declared
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