Very-low-dose twice-daily aspirin maintains platelet inhibition and improves haemostasis during dual-antiplatelet therapy for acute coronary syndrome.
Aspirin
P2Y inhibitors
bleeding
thromboxane
ticagrelor
Journal
Platelets
ISSN: 1369-1635
Titre abrégé: Platelets
Pays: England
ID NLM: 9208117
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
14
2
2019
medline:
18
4
2019
entrez:
14
2
2019
Statut:
ppublish
Résumé
Higher aspirin doses may be inferior in ticagrelor-treated acute coronary syndrome (ACS) patients and reducing bleeding risk whilst maintaining antithrombotic benefits could improve outcomes. We characterized the pharmacodynamics of a novel dual-antiplatelet-therapy regimen consisting of very-low-dose twice-daily (BD) aspirin with standard-dose ticagrelor. A total of 20 ticagrelor-treated ACS patients entered a randomized crossover to take aspirin 20 mg BD (12-hourly) during one 14-day period and 75 mg once-daily (OD) in the other. After 14 days of treatment, serum thromboxane (TX)B
Identifiants
pubmed: 30759035
doi: 10.1080/09537104.2019.1572880
pmc: PMC6425913
doi:
Substances chimiques
Platelet Aggregation Inhibitors
0
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
148-157Subventions
Organisme : British Heart Foundation
ID : FS/15/82/31824
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/18/49/33752
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17176
Pays : United Kingdom
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