Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment ("chemobrain"), a condition that significantly impairs the quality of life of many cancer survivors.
Blood-brain barrier
Chemotherapy-induced cognitive impairment
Mitochondrial dysfunction
Oxidative damage
TNF-alpha
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
09
11
2018
revised:
05
02
2019
accepted:
07
02
2019
pubmed:
14
2
2019
medline:
6
2
2020
entrez:
14
2
2019
Statut:
ppublish
Résumé
Increasing numbers of cancer patients survive and live longer than five years after therapy, but very often side effects of cancer treatment arise at same time. One of the side effects, chemotherapy-induced cognitive impairment (CICI), also called "chemobrain" or "chemofog" by patients, brings enormous challenges to cancer survivors following successful chemotherapeutic treatment. Decreased abilities of learning, memory, attention, executive function and processing speed in cancer survivors with CICI, are some of the challenges that greatly impair survivors' quality of life. The molecular mechanisms of CICI involve very complicated processes, which have been the subject of investigation over the past decades. Many mechanistic candidates have been studied including disruption of the blood-brain barrier (BBB), DNA damage, telomere shortening, oxidative stress and associated inflammatory response, gene polymorphism of neural repair, altered neurotransmission, and hormone changes. Oxidative stress is considered as a vital mechanism, since over 50% of FDA-approved anti-cancer drugs can generate reactive oxygen species (ROS) or reactive nitrogen species (RNS), which lead to neuronal death. In this review paper, we discuss these important candidate mechanisms, in particular oxidative stress and the cytokine, TNF-alpha and their potential roles in CICI.
Identifiants
pubmed: 30759363
pii: S0925-4439(19)30059-6
doi: 10.1016/j.bbadis.2019.02.007
pmc: PMC6502692
mid: NIHMS1521252
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1088-1097Subventions
Organisme : NCI NIH HHS
ID : R01 CA217934
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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