The blood-brain barrier and beyond: Nano-based neuropharmacology and the role of extracellular matrix.
Blood-brain barrier
Brain pathology
Extracellular matrix
Nanomedicine
Neuropharmacology
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
13
11
2018
revised:
11
01
2019
accepted:
28
01
2019
pubmed:
14
2
2019
medline:
22
11
2019
entrez:
14
2
2019
Statut:
ppublish
Résumé
Restrained drug delivery due to the blood-brain barrier (BBB) considerably limits options for the treatment of brain pathologies. The utilization of nanoparticulate (NP) carriers has been proposed as a solution. The development strategies need to address the important hurdle of NP passage across the BBB as well as the altered cellular up-take due to the pathophysiological changes of the damaged or diseased tissue as well as immunological and toxicological aspects of nanomedicine penetration. This review therefore scopes to: 1) outline the state-of-the art knowledge on BBB passage, 2) address the significant influence of pathological conditions on nanoparticulate drug delivery, and, 3) highlight the largely neglected role of the extracellular matrix (ECM). Interactions of the nanosystem with biological barriers, cells and ECM in the milieu of brain pathologies are critically discussed in order to present a holistic overview of the advances and pits of nanomedicine applications in brain disease.
Identifiants
pubmed: 30759369
pii: S1549-9634(19)30028-0
doi: 10.1016/j.nano.2019.01.016
pii:
doi:
Substances chimiques
Delayed-Action Preparations
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
359-379Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.