Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.

Animals DNA (Cytosine-5-)-Methyltransferases / antagonists & inhibitors DNA Methylation DNA Methyltransferase 3A Encephalomyelitis, Autoimmune, Experimental / genetics Epigenesis, Genetic Female Forkhead Transcription Factors / biosynthesis Genomic Imprinting Interleukin-6 / immunology Male Mice Mice, Inbred C57BL Positive Regulatory Domain I-Binding Factor 1 / genetics T-Lymphocytes, Regulatory / immunology
Blimp1 CNS CNS2 DNA methyltransferases Foxp3 Interleukin-6 epigenetic regulation inflammation regulatory T cells

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
12 02 2019
Historique:
received: 08 02 2018
revised: 13 12 2018
accepted: 17 01 2019
entrez: 14 2 2019
pubmed: 14 2 2019
medline: 22 4 2020
Statut: ppublish

Résumé

Foxp3

Identifiants

DOI: 10.1016/j.celrep.2019.01.070 PMID: 30759395 PMC: PMC6389594
pubmed: 30759395
pii: S2211-1247(19)30099-3
doi: 10.1016/j.celrep.2019.01.070
pmc: PMC6389594
pii:
doi:

Substances chimiques

Dnmt3a protein, mouse 0
Forkhead Transcription Factors 0
Foxp3 protein, mouse 0
Interleukin-6 0
Prdm1 protein, mouse 0
interleukin-6, mouse 0
Positive Regulatory Domain I-Binding Factor 1 EC 2.1.1.-
DNA (Cytosine-5-)-Methyltransferases EC 2.1.1.37
DNA Methyltransferase 3A EC 2.1.1.37

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1854-1868.e5

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI057459
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA134777
Pays : United States

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Garima Garg (G)

Klinikum Rechts der Isar, Department of Experimental Neuroimmunology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.

Andreas Muschaweckh (A)

Klinikum Rechts der Isar, Department of Experimental Neuroimmunology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.

Helena Moreno (H)

Biomedical Center (BMC) and Center for Integrated Protein Science Munich, Faculty of Medicine, LMU Munich, Grosshaderner Str. 9, 82152 Planegg-Martinsried, Germany.

Ajithkumar Vasanthakumar (A)

The Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St., Melbourne Victoria 3000, Australia; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

Stefan Floess (S)

Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany.

Gildas Lepennetier (G)

Klinikum Rechts der Isar, Department of Experimental Neuroimmunology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.

Rupert Oellinger (R)

Institute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany; Klinikum Rechts der Isar, Department of Medicine II, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.

Yifan Zhan (Y)

The Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St., Melbourne Victoria 3000, Australia; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

Tommy Regen (T)

Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.

Michael Hiltensperger (M)

Klinikum Rechts der Isar, Department of Experimental Neuroimmunology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.

Christian Peter (C)

Klinikum Rechts der Isar, Department of Experimental Neuroimmunology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.

Lilian Aly (L)

Klinikum Rechts der Isar, Department of Experimental Neuroimmunology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377 Munich, Germany.

Benjamin Knier (B)

Klinikum Rechts der Isar, Department of Experimental Neuroimmunology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.

Lakshmi Reddy Palam (LR)

Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 West Walnut St., Indianapolis, IN 46202, USA.

Reuben Kapur (R)

Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 West Walnut St., Indianapolis, IN 46202, USA.

Mark H Kaplan (MH)

Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 West Walnut St., Indianapolis, IN 46202, USA.

Ari Waisman (A)

Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.

Roland Rad (R)

Institute of Molecular Oncology and Functional Genomics, TranslaTUM Cancer Center, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany; Klinikum Rechts der Isar, Department of Medicine II, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.

Gunnar Schotta (G)

Biomedical Center (BMC) and Center for Integrated Protein Science Munich, Faculty of Medicine, LMU Munich, Grosshaderner Str. 9, 82152 Planegg-Martinsried, Germany.

Jochen Huehn (J)

Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany.

Axel Kallies (A)

The Peter Doherty Institute for Infection and Immunity, University of Melbourne, 792 Elizabeth St., Melbourne Victoria 3000, Australia; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

Thomas Korn (T)

Klinikum Rechts der Isar, Department of Experimental Neuroimmunology, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Feodor-Lynen-Str. 17, 81377 Munich, Germany. Electronic address: thomas.korn@tum.de.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › DNA modification methylases › DNA-Cytosine Methylases › DNA (cytosine-5-)-methyltransferase › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › DNA modification methylases › DNA-Cytosine Methylases › DNA (cytosine-5-)-methyltransferase › DNA methyltransferase 3A › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Empreinte génomique › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Facteur-1 liant le domaine de régulation positive I › Blimp1 Prevents Methylation of Foxp3 and Loss...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Blimp1 Prevents Methylation of Foxp3 and Loss...