Inflammasome Signaling and Impaired Vascular Health in Psoriasis.
Adult
Aorta
/ cytology
Cell Adhesion Molecules
/ biosynthesis
Cells, Cultured
Cytokines
/ biosynthesis
Endothelial Cells
/ drug effects
Female
Gene Expression Profiling
Humans
Inflammasomes
/ metabolism
Male
Middle Aged
NF-kappa B
/ metabolism
Proteome
Psoriasis
/ blood
RNA, Messenger
/ biosynthesis
Receptors, Cytokine
/ biosynthesis
Signal Transduction
Transcription, Genetic
Transcriptome
cardiovascular disease
endothelium
inflammasome
inflammation
psoriasis
Journal
Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
pubmed:
15
2
2019
medline:
14
1
2020
entrez:
15
2
2019
Statut:
ppublish
Résumé
Objective- Psoriasis is an inflammatory skin disease which heightens the risk of cardiovascular disease. This study directly investigated vascular endothelial health and systemically altered pathways in psoriasis and matched controls. Approach and Results- Twenty patients (mean age, 40 years; 50% male) with active psoriasis and 10 age-, sex-matched controls were recruited. To investigate systemically alerted pathways, a deep sequencing omics approach was applied, including unbiased blood transcriptomic and targeted proteomic analysis. Vascular endothelial health was assessed by transcriptomic profiling of endothelial cells obtained from the brachial veins of recruited participants. Blood transcriptomic profiling identified inflammasome signaling as the highest differentially expressed canonical pathway ( Z score 1.6; P=1×10
Identifiants
pubmed: 30760013
doi: 10.1161/ATVBAHA.118.312246
pmc: PMC6436998
mid: NIHMS1520431
doi:
Substances chimiques
Cell Adhesion Molecules
0
Cytokines
0
Inflammasomes
0
NF-kappa B
0
Proteome
0
RNA, Messenger
0
Receptors, Cytokine
0
Banques de données
ClinicalTrials.gov
['NCT03228017']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
787-798Subventions
Organisme : NCATS NIH HHS
ID : TL1 TR001447
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001445
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114978
Pays : United States
Organisme : NHLBI NIH HHS
ID : L30 HL143703
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL106041
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL098129
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139909
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001446
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL106041
Pays : United States
Références
Biomed Res Int. 2014;2014:893106
pubmed: 24868552
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
J Invest Dermatol. 2011 Mar;131(3):670-6
pubmed: 21191419
Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):2045-51
pubmed: 22895665
Ann Rheum Dis. 2013 May;72(5):754-60
pubmed: 22915623
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
Curr Pharm Des. 2005;11(17):2163-75
pubmed: 16026286
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Circ Res. 2006 Feb 3;98(2):200-8
pubmed: 16373601
Circulation. 2008 Apr 29;117(17):2270-8
pubmed: 18413499
Curr Rheumatol Rep. 2012 Aug;14(4):343-8
pubmed: 22562431
Cardiovasc Res. 2010 Jul 1;87(1):12-21
pubmed: 20427336
Nat Commun. 2015 Oct 28;6:8761
pubmed: 26508369
Circ Cardiovasc Imaging. 2018 Jun;11(6):e007849
pubmed: 29807889
Circulation. 2010 Mar 2;121(8):1014-21
pubmed: 20159829
J Appl Physiol (1985). 2007 Nov;103(5):1873-8
pubmed: 17717122
Clin Rev Allergy Immunol. 2013 Apr;44(2):194-204
pubmed: 22359071
J Intern Med. 2011 Aug;270(2):147-57
pubmed: 21114692
Cytokine. 2015 Jun;73(2):342-50
pubmed: 25585875
Sci Rep. 2017 Oct 23;7(1):13831
pubmed: 29062018
J Neuroinflammation. 2015 Jul 30;12:137
pubmed: 26224068
Adv Med Sci. 2015 Sep;60(2):349-54
pubmed: 26318079
Arthritis Rheumatol. 2018 Mar;70(3):408-416
pubmed: 29088580
Exp Dermatol. 2011 Jul;20(7):544-9
pubmed: 21692858
Circ Res. 2018 Feb 16;122(4):568-582
pubmed: 29301854
Arch Dermatol. 2011 Sep;147(9):1031-9
pubmed: 21576552
Sci Transl Med. 2016 Jan 6;8(320):320ra1
pubmed: 26738794
Circ Res. 2016 Jan 8;118(1):145-56
pubmed: 26837745
J Invest Dermatol. 2013 Feb;133(2):377-85
pubmed: 23014338
Circulation. 2017 Jul 18;136(3):263-276
pubmed: 28483812
Blood. 2007 Jan 15;109(2):613-5
pubmed: 16990601
Curr Atheroscler Rep. 2017 Oct 17;19(12):48
pubmed: 29038899
Heart. 2006 Apr;92(4):441-4
pubmed: 16159981
Nat Rev Immunol. 2007 Oct;7(10):803-15
pubmed: 17893694
Sci Rep. 2016 Mar 15;6:22745
pubmed: 26976200
JAMA. 2006 Oct 11;296(14):1735-41
pubmed: 17032986
Am J Cardiovasc Dis. 2011;1(3):244-54
pubmed: 22254202
Cell Death Dis. 2018 Jan 18;9(2):24
pubmed: 29348630
J Am Acad Dermatol. 2017 Oct;77(4):650-656.e3
pubmed: 28826925
Genome Biol. 2010;11(10):R106
pubmed: 20979621
Ther Adv Musculoskelet Dis. 2015 Oct;7(5):187-95
pubmed: 26425147
Am J Cardiovasc Dis. 2013 Nov 01;3(4):273-8
pubmed: 24224139
Circulation. 2007 Mar 13;115(10):1285-95
pubmed: 17353456
Clin Rev Allergy Immunol. 2007 Oct;33(1-2):45-56
pubmed: 18094946
Circ Cardiovasc Imaging. 2018 Jun;11(6):e007394
pubmed: 29776990
J Invest Dermatol. 2010 Jul;130(7):1785-96
pubmed: 20445552
J Am Coll Cardiol. 2014 Jul 1;63(25 Pt B):2935-2959
pubmed: 24239921
Annu Rev Immunol. 2014;32:227-55
pubmed: 24655295
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Nature. 2002 Dec 19-26;420(6917):868-74
pubmed: 12490960
J Am Acad Dermatol. 2014 Jun;70(6):1137-8
pubmed: 24641984
Autoimmun Rev. 2017 Sep;16(9):984-991
pubmed: 28705781
J Cardiol. 2009 Jun;53(3):317-33
pubmed: 19477372
J Immunol. 2009 Jul 15;183(2):787-91
pubmed: 19570822
Protein Cell. 2013 Mar;4(3):163-7
pubmed: 23483477
Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H867-H873
pubmed: 28258057
Arch Immunol Ther Exp (Warsz). 2013 Feb;61(1):1-14
pubmed: 23224338
Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2667-76
pubmed: 26449753
J Invest Dermatol. 2018 Feb;138(2):273-281
pubmed: 28927890
Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651
pubmed: 20457564
J Immunol. 2008 Nov 15;181(10):7420-7
pubmed: 18981165
Med Hypotheses. 2009 Mar;72(3):327-9
pubmed: 19022587
J Eur Acad Dermatol Venereol. 2012 Mar;26 Suppl 2:3-11
pubmed: 22356630
Signal Transduct Target Ther. 2017;2:
pubmed: 29158945
Nat Rev Dis Primers. 2016 Nov 24;2:16082
pubmed: 27883001
JAMA Cardiol. 2017 Sep 1;2(9):1013-1018
pubmed: 28564678
J Am Acad Dermatol. 2013 Dec;69(6):1014-24
pubmed: 24238156
Circulation. 2004 Jun 15;109(23 Suppl 1):III27-32
pubmed: 15198963
Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2658-68
pubmed: 25341795