Human G protein-coupled receptor 30 is
G-protein-coupled receptors
endocytosis
estrogens
extracellular signal-regulated kinases
glycosylation
trafficking
Journal
Bioscience reports
ISSN: 1573-4935
Titre abrégé: Biosci Rep
Pays: England
ID NLM: 8102797
Informations de publication
Date de publication:
28 02 2019
28 02 2019
Historique:
received:
19
12
2018
revised:
12
02
2019
accepted:
12
02
2019
pubmed:
15
2
2019
medline:
29
1
2020
entrez:
15
2
2019
Statut:
epublish
Résumé
G protein-coupled receptor 30 (GPR30), or G protein-coupled estrogen receptor (GPER), is a G protein-coupled receptor (GPCR) that is currently attracting considerable attention in breast cancer and cardiometabolic regulation. The receptor was reported to be a novel membrane estrogen receptor mediating rapid non-genomic responses. However, questions remain about both the cognate ligand and the subcellular localization of receptor activity. Here, we used human embryonic kidney (HEK) 293 (HEK293) cells ectopically expressing N-terminally FLAG-tagged human GPR30 and three unique antibodies (Ab) specifically targetting the receptor N-terminal domain (N-domain) to investigate the role of
Identifiants
pubmed: 30760632
pii: BSR20182436
doi: 10.1042/BSR20182436
pmc: PMC6390128
pii:
doi:
Substances chimiques
GPER1 protein, human
0
Receptors, Estrogen
0
Receptors, G-Protein-Coupled
0
Asparagine
7006-34-0
MAPK1 protein, human
EC 2.7.11.24
MAPK3 protein, human
EC 2.7.11.24
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019 The Author(s).
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