Antimicrobial and inflammatory properties of South African clinical Lactobacillus isolates and vaginal probiotics.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
13 02 2019
Historique:
received: 08 08 2018
accepted: 17 12 2018
entrez: 15 2 2019
pubmed: 15 2 2019
medline: 6 8 2020
Statut: epublish

Résumé

Bacterial vaginosis (BV) causes genital inflammation and increased HIV acquisition risk. The standard-of-care for BV, antibiotic therapy, is associated with high recurrence rates. Probiotics may improve treatment outcomes, although substantial heterogeneity in efficacy has been observed during clinical trials. To evaluate the potential to improve existing probiotics, we compared the inflammatory and antimicrobial (adhesion, H

Identifiants

pubmed: 30760770
doi: 10.1038/s41598-018-38253-4
pii: 10.1038/s41598-018-38253-4
pmc: PMC6374385
doi:

Types de publication

Clinical Trial Comparative Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1917

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom

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Auteurs

Emily Chetwin (E)

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.

Monalisa T Manhanzva (MT)

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.

Andrea G Abrahams (AG)

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.

Remy Froissart (R)

UMR 5290 MIVEGEC, French National Centre for Scientific Research (CNRS), Montpellier, France.

Hoyam Gamieldien (H)

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.

Heather Jaspan (H)

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Seattle Children's Research Institute, University of Washington, Seattle, Washington, USA.

Shameem Z Jaumdally (SZ)

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.

Shaun L Barnabas (SL)

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.

Smritee Dabee (S)

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.

Anna-Ursula Happel (AU)

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.

Desiree Bowers (D)

Department of Human Biology, University of Cape Town, Cape Town, South Africa.

Lester Davids (L)

Department of Human Biology, University of Cape Town, Cape Town, South Africa.

Jo-Ann S Passmore (JS)

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Centre for the AIDS Programme of Research in South Africa (CAPRISA) Centre of Excellence in HIV Prevention, Durban, South Africa.
National Health Laboratory Service, Cape Town, South Africa.

Lindi Masson (L)

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa. L.Masson@uct.ac.za.
Centre for the AIDS Programme of Research in South Africa (CAPRISA) Centre of Excellence in HIV Prevention, Durban, South Africa. L.Masson@uct.ac.za.

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