Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution.

Animals Brain / cytology Case-Control Studies Cell Separation Demyelinating Diseases / pathology Female Humans Kinetics Male Mice Microglia / classification Multiple Sclerosis / pathology Neurodegenerative Diseases / pathology Single-Cell Analysis Spatio-Temporal Analysis

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2019
Historique:
received: 01 02 2018
accepted: 11 01 2019
pubmed: 15 2 2019
medline: 14 8 2019
entrez: 15 2 2019
Statut: ppublish

Résumé

Microglia have critical roles not only in neural development and homeostasis, but also in neurodegenerative and neuroinflammatory diseases of the central nervous system

Identifiants

DOI: 10.1038/s41586-019-0924-x PMID: 30760929
pubmed: 30760929
doi: 10.1038/s41586-019-0924-x
pii: 10.1038/s41586-019-0924-x
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

388-392

Subventions

Organisme : Medical Research Council
ID : MC_PC_16031
Pays : United Kingdom

Commentaires et corrections

Type : ErratumIn
Type : CommentIn

Auteurs

Takahiro Masuda (T)

Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.

Roman Sankowski (R)

Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.
Berta-Ottenstein-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Ori Staszewski (O)

Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.

Chotima Böttcher (C)

Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Lukas Amann (L)

Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.
Faculty of Biology, University of Freiburg, Freiburg, Germany.
Max Planck Institute of Immunobiology and Epigenetics (MPI-IE), Freiburg, Germany.

Christian Scheiwe (C)

Clinic for Neurosurgery, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Stefan Nessler (S)

Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.

Patrik Kunz (P)

Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.

Geert van Loo (G)

VIB Center for Inflammation Research, Ghent, Belgium.
Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

Volker Arnd Coenen (VA)

Department of Stereotactic and Functional Neurosurgery, Medical Faculty, University of Freiburg, Freiburg, Germany.

Peter Christoph Reinacher (PC)

Department of Stereotactic and Functional Neurosurgery, Medical Faculty, University of Freiburg, Freiburg, Germany.

Anna Michel (A)

Department of Neurosurgery, University Hospital Essen, Essen, Germany.

Ulrich Sure (U)

Department of Neurosurgery, University Hospital Essen, Essen, Germany.

Ralf Gold (R)

Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.

Dominic Grün (D)

Max Planck Institute of Immunobiology and Epigenetics (MPI-IE), Freiburg, Germany.

Josef Priller (J)

Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité - Universitätsmedizin Berlin, Berlin, Germany.
DZNE, Berlin, Germany.
UK DRI, University of Edinburgh, Edinburgh, UK.

Christine Stadelmann (C)

Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.

Marco Prinz (M)

Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany. marco.prinz@uniklinik-freiburg.de.
Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. marco.prinz@uniklinik-freiburg.de.
Center for NeuroModulation, Faculty of Medicine, University of Freiburg, Frieburg, Germany. marco.prinz@uniklinik-freiburg.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Séparation cellulaire › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Maladies du système nerveux › Maladies démyélinisantes › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Spatial and temporal heterogeneity of mouse...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse spatiale › Analyse spatio-temporelle › Spatial and temporal heterogeneity of mouse...