Influenza Virus Neuraminidase Structure and Functions.
HA:NA balance
NA
hemagglutinin
infection
influenza
neuraminidase
sialic acid
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
10
2018
accepted:
10
01
2019
entrez:
15
2
2019
pubmed:
15
2
2019
medline:
15
2
2019
Statut:
epublish
Résumé
With the constant threat of emergence of a novel influenza virus pandemic, there must be continued evaluation of the molecular mechanisms that contribute to virulence. Although the influenza A virus surface glycoprotein neuraminidase (NA) has been studied mainly in the context of its role in viral release from cells, accumulating evidence suggests it plays an important, multifunctional role in virus infection and fitness. This review investigates the various structural features of NA, linking these with functional outcomes in viral replication. The contribution of evolving NA activity to viral attachment, entry and release of virions from infected cells, and maintenance of functional balance with the viral hemagglutinin are also discussed. Greater insight into the role of this important antiviral drug target is warranted.
Identifiants
pubmed: 30761095
doi: 10.3389/fmicb.2019.00039
pmc: PMC6362415
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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