Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures.
Animals
Antiviral Agents
/ pharmacology
Cell Line
Computational Biology
/ methods
Disease Models, Animal
Drug Repositioning
Drug Therapy, Combination
Female
Gene Expression Profiling
Gene Expression Regulation
Host-Pathogen Interactions
/ genetics
Humans
Influenza A virus
/ drug effects
Influenza, Human
/ drug therapy
Mice
Orthomyxoviridae Infections
/ drug therapy
Pharmacogenomic Testing
Respiratory Mucosa
/ immunology
Transcriptome
Virus Replication
/ drug effects
antivirals
drug repurposing
host targeting
influenza viruses
inhibitors of viral infection
transcriptome
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
18
09
2018
accepted:
10
01
2019
entrez:
15
2
2019
pubmed:
15
2
2019
medline:
21
12
2019
Statut:
epublish
Résumé
Influenza virus infections remain a major and recurrent public health burden. The intrinsic ever-evolving nature of this virus, the suboptimal efficacy of current influenza inactivated vaccines, as well as the emergence of resistance against a limited antiviral arsenal, highlight the critical need for novel therapeutic approaches. In this context, the aim of this study was to develop and validate an innovative strategy for drug repurposing as host-targeted inhibitors of influenza viruses and the rapid evaluation of the most promising candidates in Phase II clinical trials. We exploited
Identifiants
pubmed: 30761132
doi: 10.3389/fimmu.2019.00060
pmc: PMC6361841
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
60Subventions
Organisme : CIHR
ID : 229733
Pays : Canada
Organisme : CIHR
ID : 230187
Pays : Canada
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