Mesenchymal Stem Cell Therapy for Osteoarthritis: The Critical Role of the Cell Secretome.
chondroprotection
immunomodulation
mesenchymal stem cells
osteoarthristis
paracrine action
secretome
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2019
2019
Historique:
received:
14
08
2018
accepted:
11
01
2019
entrez:
15
2
2019
pubmed:
15
2
2019
medline:
15
2
2019
Statut:
epublish
Résumé
Osteoarthritis (OA) is an inflammatory condition still lacking effective treatments. Mesenchymal stem/stromal cells (MSCs) have been successfully employed in pre-clinical models aiming to resurface the degenerated cartilage. In early-phase clinical trials, intra-articular (IA) administration of MSCs leads to pain reduction and cartilage protection or healing. However, the consistent lack of engraftment indicates that the observed effect is delivered through a "hit-and-run" mechanism, by a temporal release of paracrine molecules. MSCs express a variety of chemokines and cytokines that aid in repair of degraded tissue, restoration of normal tissue metabolism and, most importantly, counteracting inflammation. Secretion of therapeutic factors is increased upon licensing by inflammatory signals or apoptosis, induced by the host immune system. Trophic effectors are released as soluble molecules or carried by extracellular vesicles (ECVs). This review provides an overview of the functions and mechanisms of MSC-secreted molecules found to be upregulated in models of OA, whether using
Identifiants
pubmed: 30761298
doi: 10.3389/fbioe.2019.00009
pmc: PMC6361779
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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