Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3.
Animals
COS Cells
Chlorocebus aethiops
Cyclic AMP-Dependent Protein Kinases
/ metabolism
Insulin-Like Growth Factor I
/ metabolism
Organic Anion Transporters, Sodium-Independent
/ metabolism
SUMO-1 Protein
/ metabolism
Small Ubiquitin-Related Modifier Proteins
/ metabolism
Sumoylation
Transfection
Ubiquitin-Conjugating Enzymes
/ metabolism
Ubiquitins
/ metabolism
SUMOylation
drug transport
organic anion transporter
protein kinase A
regulation
Journal
The AAPS journal
ISSN: 1550-7416
Titre abrégé: AAPS J
Pays: United States
ID NLM: 101223209
Informations de publication
Date de publication:
13 02 2019
13 02 2019
Historique:
received:
15
11
2018
accepted:
22
01
2019
entrez:
15
2
2019
pubmed:
15
2
2019
medline:
15
2
2020
Statut:
epublish
Résumé
Organic anion transporter 3 (OAT3) plays a vital role in removing a broad variety of anionic drugs from kidney, thus avoiding their possible toxicity in the body. We earlier established that activation of protein kinase C (PKC) enhances OAT3 ubiquitination, which promotes OAT3 internalization from the cell plasma membrane to intracellular endosomes and consequent degradation. As a result, OAT3 expression and transport activity are reduced. In the current study, we discovered that protein kinase A (PKA) had an opposite effect to PKC on the regulation of OAT3. We showed that activation of PKA by Bt2-cAMP stimulated OAT3 transport activity, which was largely caused by an enhanced plasma membrane expression of the transporter, kinetically reflected as an augmented maximal transport velocity V
Identifiants
pubmed: 30761470
doi: 10.1208/s12248-019-0303-4
pii: 10.1208/s12248-019-0303-4
pmc: PMC6647857
mid: NIHMS1041849
doi:
Substances chimiques
IGF1 protein, human
0
Organic Anion Transporters, Sodium-Independent
0
SUMO-1 Protein
0
SUMO1 protein, human
0
SUMO2 protein, human
0
SUMO3 protein, human
0
Small Ubiquitin-Related Modifier Proteins
0
Ubiquitins
0
organic anion transport protein 3
0
Insulin-Like Growth Factor I
67763-96-6
Ubiquitin-Conjugating Enzymes
EC 2.3.2.23
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
ubiquitin-conjugating enzyme UBC9
EC 6.3.2.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
30Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM079123
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM097000
Pays : United States
Références
Cell. 2005 Apr 8;121(1):37-47
pubmed: 15820677
J Biol Chem. 2008 Nov 21;283(47):32570-9
pubmed: 18818201
Int J Biochem Mol Biol. 2012;3(2):242-9
pubmed: 22773962
EMBO J. 1998 Jan 2;17(1):61-70
pubmed: 9427741
Nat Rev Endocrinol. 2014 Apr;10(4):243-8
pubmed: 24566817
Drug Metab Dispos. 2014 Dec;42(12):2041-8
pubmed: 25239859
Cell Cycle. 2003 Nov-Dec;2(6):528-30
pubmed: 14504467
Mol Metab. 2015 Feb 03;4(4):265-76
pubmed: 25830090
J Biol Chem. 2017 Sep 22;292(38):15789-15803
pubmed: 28765282
Am J Kidney Dis. 2015 Feb;65(2):327-36
pubmed: 25151409
Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1125-30
pubmed: 10655495
Biochem Pharmacol. 2007 Feb 1;73(3):440-9
pubmed: 17137557
J Biol Chem. 2005 Nov 18;280(46):38153-9
pubmed: 16144832
In Vivo. 2016 Jul-Aug;30(4):375-81
pubmed: 27381597
Endocrinol Metab Clin North Am. 2012 Jun;41(2):231-47, v
pubmed: 22682628
Mol Cell. 2008 Nov 7;32(3):301-5
pubmed: 18995828
Nat Cell Biol. 2008 Jun;10(6):654-64
pubmed: 18469808
Mol Pharmacol. 2011 May;79(5):795-805
pubmed: 21325265
Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G406-13
pubmed: 19074644
Mol Pharmacol. 2009 Sep;76(3):481-90
pubmed: 19515966
Nat Rev Mol Cell Biol. 2010 Dec;11(12):861-71
pubmed: 21102611
Xenobiotica. 2008 Jul;38(7-8):889-935
pubmed: 18668434
Biochim Biophys Acta. 2003 Dec 30;1618(2):185-93
pubmed: 14729155
Pharm Res. 2010 Apr;27(4):589-96
pubmed: 20140636
Trends Cell Biol. 2005 Oct;15(10):525-32
pubmed: 16125934
Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10743-8
pubmed: 20498050
Eur J Pharmacol. 2010 Feb 10;627(1-3):49-55
pubmed: 19878671
Med Res Rev. 2002 Nov;22(6):602-16
pubmed: 12369090
J Biol Chem. 2009 Jan 30;284(5):2672-9
pubmed: 19028678
Horm Res Paediatr. 2015;83(5):345-57
pubmed: 25824333
Am J Med Sci. 2014 Mar;347(3):221-7
pubmed: 23470271
Drug Metab Dispos. 2017 Aug;45(8):887-895
pubmed: 28572241
Int J Biochem Mol Biol. 2012;3(3):322-7
pubmed: 23097748
Biopharm Drug Dispos. 2010 Jan;31(1):1-71
pubmed: 19953504
Biopharm Drug Dispos. 2017 Nov;38(8):449-457
pubmed: 28608480
Drug Metab Dispos. 2013 Oct;41(10):1825-34
pubmed: 23920220
Am J Physiol Renal Physiol. 2004 Nov;287(5):F1021-9
pubmed: 15238352
Mol Pharmacol. 2013 Jan;83(1):217-24
pubmed: 23087261
J Neurosci. 2005 Mar 16;25(11):2838-52
pubmed: 15772344
Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F330-8
pubmed: 25477469
Mol Cell. 1998 Aug;2(2):233-9
pubmed: 9734360
Biochem Pharmacol. 2016 Feb 15;102:120-129
pubmed: 26740304
Mol Cell Biol. 2003 Apr;23(8):2953-68
pubmed: 12665592