Staphylococcus aureus TarP: A Brick in the Wall or Rosetta Stone?
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
13 02 2019
13 02 2019
Historique:
entrez:
15
2
2019
pubmed:
15
2
2019
medline:
14
5
2019
Statut:
ppublish
Résumé
Staphylococcus aureus infection elicits antibodies against wall teichoic acid (WTA). Several glycosyltransferases modify WTA to generate anomeric heterogeneity. In recent work, Gerlach et al. (2018) show that modification by prophage-encoded TarP diminishes WTA immunogenicity, allowing staphylococci to evade host adaptive immune responses, and propose to exploit these insights for vaccines.
Identifiants
pubmed: 30763532
pii: S1931-3128(19)30051-4
doi: 10.1016/j.chom.2019.01.013
pmc: PMC6724547
mid: NIHMS1048075
pii:
doi:
Substances chimiques
Antibodies
0
Streptococcal Vaccines
0
Teichoic Acids
0
Glycosyltransferases
EC 2.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
182-183Subventions
Organisme : NIAID NIH HHS
ID : R01 AI110937
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Références
J Biol Chem. 1962 Dec;237:3839-41
pubmed: 13937701
Lancet Infect Dis. 2005 Dec;5(12):751-62
pubmed: 16310147
J Exp Med. 1917 Oct 1;26(4):477-93
pubmed: 19868163
Annu Rev Microbiol. 2013;67:629-50
pubmed: 23834243
J Biol Chem. 2013 Oct 25;288(43):30956-68
pubmed: 24045948
Int J Med Microbiol. 2014 May;304(3-4):215-21
pubmed: 24365646
Clin Microbiol Rev. 2015 Jul;28(3):603-61
pubmed: 26016486
Nature. 2015 Nov 19;527(7578):323-8
pubmed: 26536114
Nature. 2018 Nov;563(7733):705-709
pubmed: 30464342
N Engl J Med. 1994 Apr 21;330(16):1107-13
pubmed: 8133853