Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors.

Adult Bifidobacterium / genetics Breast Feeding Cohort Studies DNA, Bacterial / genetics Female Firmicutes / genetics Humans Infant Longitudinal Studies Male Maternal Age Maternal Health Milk, Human / microbiology Proteobacteria / genetics Sex Factors
CHILD Study breastfeeding breastmilk human milk infant microbiome microbiota mode of breastfeeding nutrition

Journal

Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316

Informations de publication

Date de publication:
13 02 2019
Historique:
received: 08 07 2018
revised: 02 11 2018
accepted: 03 01 2019
entrez: 15 2 2019
pubmed: 15 2 2019
medline: 10 7 2019
Statut: ppublish

Résumé

Breastmilk contains a complex community of bacteria that may help seed the infant gut microbiota. The composition and determinants of milk microbiota are poorly understood. Among 393 mother-infant dyads from the CHILD cohort, we found that milk microbiota at 3-4 months postpartum was dominated by inversely correlated Proteobacteria and Firmicutes, and exhibited discrete compositional patterns. Milk microbiota composition and diversity were associated with maternal factors (BMI, parity, and mode of delivery), breastfeeding practices, and other milk components in a sex-specific manner. Causal modeling identified mode of breastfeeding as a key determinant of milk microbiota composition. Specifically, providing pumped breastmilk was consistently associated with multiple microbiota parameters including enrichment of potential pathogens and depletion of bifidobacteria. Further, these data support the retrograde inoculation hypothesis, whereby the infant oral cavity impacts the milk microbiota. Collectively, these results identify features and determinants of human milk microbiota composition, with potential implications for infant health and development.

Identifiants

DOI: 10.1016/j.chom.2019.01.011 PMID: 30763539
pubmed: 30763539
pii: S1931-3128(19)30049-6
doi: 10.1016/j.chom.2019.01.011
pii:
doi:

Substances chimiques

DNA, Bacterial 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

324-335.e4

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Shirin Moossavi (S)

Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, Canada; Children's Hospital Research Institute of Manitoba, Pediatrics and Child Health, Winnipeg, MB, Canada; Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Winnipeg, MB, Canada; Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Shadi Sepehri (S)

Children's Hospital Research Institute of Manitoba, Pediatrics and Child Health, Winnipeg, MB, Canada.

Bianca Robertson (B)

Pediatrics, University of California, San Diego, La Jolla, CA, USA.

Lars Bode (L)

Pediatrics, University of California, San Diego, La Jolla, CA, USA; Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, La Jolla, CA, USA.

Sue Goruk (S)

Agricultural Food, and Nutritional Science, University of Alberta, Edmonton, AB, Canada.

Catherine J Field (CJ)

Agricultural Food, and Nutritional Science, University of Alberta, Edmonton, AB, Canada.

Lisa M Lix (LM)

Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Russell J de Souza (RJ)

Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Nutritional Sciences, University of Toronto, Toronto, ON, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Allan B Becker (AB)

Children's Hospital Research Institute of Manitoba, Pediatrics and Child Health, Winnipeg, MB, Canada; Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Winnipeg, MB, Canada.

Piushkumar J Mandhane (PJ)

Pediatrics, University of Alberta, Edmonton, AB, Canada.

Stuart E Turvey (SE)

Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Padmaja Subbarao (P)

Division of Respiratory Medicine, Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Physiology, University of Toronto, Toronto, ON, Canada.

Theo J Moraes (TJ)

Division of Respiratory Medicine, Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Diana L Lefebvre (DL)

Medicine, McMaster University, Hamilton, ON, Canada.

Malcolm R Sears (MR)

Medicine, McMaster University, Hamilton, ON, Canada.

Ehsan Khafipour (E)

Children's Hospital Research Institute of Manitoba, Pediatrics and Child Health, Winnipeg, MB, Canada; Animal Science, University of Manitoba, Winnipeg, MB, Canada.

Meghan B Azad (MB)

Children's Hospital Research Institute of Manitoba, Pediatrics and Child Health, Winnipeg, MB, Canada; Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Winnipeg, MB, Canada. Electronic address: meghan.azad@umanitoba.ca.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Composition and Variation of the Human Milk...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes irréguliers à Gram positif › Actinobacteria › Bifidobacterium › Composition and Variation of the Human Milk...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Comportement alimentaire › Allaitement naturel › Composition and Variation of the Human Milk...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Composition and Variation of the Human Milk...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN bactérien › Composition and Variation of the Human Milk...
questionsmedicales.fr › Bactéries › Firmicutes › Composition and Variation of the Human Milk...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Composition and Variation of the Human Milk...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Composition and Variation of the Human Milk...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Composition and Variation of the Human Milk...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Âge maternel › Composition and Variation of the Human Milk...
questionsmedicales.fr › Caractéristiques de la population › Santé › Santé des femmes › Santé maternelle › Composition and Variation of the Human Milk...
questionsmedicales.fr › Aliments et boissons › Aliments › Produits laitiers › Lait › Lait humain › Composition and Variation of the Human Milk...
questionsmedicales.fr › Bactéries › Proteobacteria › Composition and Variation of the Human Milk...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs sexuels › Composition and Variation of the Human Milk...