Clinical and cortical decline in the aphasic variant of Alzheimer's disease.

Alzheimer Disease / diagnostic imaging Amyloid beta-Peptides / genetics Aphasia, Primary Progressive / diagnostic imaging Atrophy / pathology Biomarkers Brain / pathology Disease Progression Female Humans Longitudinal Studies Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Positron-Emission Tomography
Amyloid PET Biomarker FreeSurfer Frontotemporal dementia Frontotemporal lobar degeneration Neuropsychology Primary progressive aphasia Progression Volumetric MRI

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
04 2019
Historique:
received: 18 07 2018
revised: 18 10 2018
accepted: 02 12 2018
pubmed: 16 2 2019
medline: 28 4 2020
entrez: 16 2 2019
Statut: ppublish

Résumé

Primary progressive aphasia (PPA) displays variable progression trajectories that require further elucidation. Longitudinal quantitation of atrophy and language over 12 months was completed for PPA patients with and without positive amyloid PET (PPA Over 12 months, both PPA groups showed significantly greater cortical atrophy rates in the left versus right hemisphere, with a more widespread pattern in PPA Preferential language network neurodegeneration is present in PPA irrespective of amyloid status. Clinical and anatomical progression appears to differ for PPA due to Alzheimer's disease versus non-Alzheimer's disease neuropathology, a distinction that may help to inform prognosis and the design of intervention trials.

Identifiants

DOI: 10.1016/j.jalz.2018.12.003 PMID: 30765195 PMC: PMC6461481
pubmed: 30765195
pii: S1552-5260(18)33620-3
doi: 10.1016/j.jalz.2018.12.003
pmc: PMC6461481
mid: NIHMS1015313
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

543-552

Subventions

Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG056258
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC008552
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075075
Pays : United States

Informations de copyright

Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

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Auteurs

Emily Joy Rogalski (EJ)

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL, USA; NU Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL, USA. Electronic address: erogalski@gmail.com.

Jaiashre Sridhar (J)

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL, USA.

Adam Martersteck (A)

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL, USA.

Benjamin Rader (B)

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL, USA.

Derin Cobia (D)

Department of Psychology, Brigham Young University, Provo, UT, USA.

Anupa K Arora (AK)

Avid Radiopharmaceuticals Inc, Philadelphia, PA, USA.

Angela J Fought (AJ)

NU Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL, USA.

Eileen H Bigio (EH)

NU Feinberg School of Medicine, Department of Pathology, Chicago, IL, USA.

Sandra Weintraub (S)

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL, USA; NU Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL, USA.

Marek-Marsel Mesulam (MM)

Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL, USA; NU Feinberg School of Medicine, Department of Neurology, Chicago, IL, USA.

Alfred Rademaker (A)

NU Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL, USA.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Aphasie progressive primaire › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Clinical and cortical decline in the aphasic...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Clinical and cortical decline in the aphasic...