Association between DNA methylation in obesity-related genes and body mass index percentile in adolescents.
Adolescent
Basic Helix-Loop-Helix Transcription Factors
/ genetics
Body Mass Index
Cohort Studies
CpG Islands
/ genetics
Cross-Sectional Studies
DNA
/ genetics
DNA Methylation
/ genetics
Epigenesis, Genetic
/ genetics
Epigenomics
/ methods
Female
Genome-Wide Association Study
Humans
Male
Obesity
/ genetics
Pediatric Obesity
/ genetics
Repressor Proteins
/ genetics
Risk Factors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 02 2019
14 02 2019
Historique:
received:
30
04
2018
accepted:
21
11
2018
entrez:
16
2
2019
pubmed:
16
2
2019
medline:
12
9
2020
Statut:
epublish
Résumé
Childhood obesity remains an epidemic in the U.S. and worldwide. However, little is understood regarding the epigenetic basis of obesity in adolescents. To investigate the cross-sectional association between DNA methylation level in obesity-related genes and body mass index (BMI) percentile, data from 263 adolescents in the population-based Penn State Child Cohort follow-up exam was analysed. Using DNA extracted from peripheral leukocytes, epigenome-wide single nucleotide resolution of DNA methylation in cytosine-phosphate-guanine (CpG) sites and surrounding regions was obtained. We used multivariable-adjusted linear regression models to assess the association between site-specific methylation level and age- and sex-specific BMI percentile. Hypergeometric and permutation tests were used to determine if obesity-related genes were significantly enriched among all intragenic sites that achieved a p < 0.05 throughout the epigenome. Among the 5,669 sites related to BMI percentile with p < 0.05, 28 were identified within obesity-related genes. Obesity-related genes were significantly enriched among 103,466 intragenic sites (P
Identifiants
pubmed: 30765773
doi: 10.1038/s41598-019-38587-7
pii: 10.1038/s41598-019-38587-7
pmc: PMC6375997
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
Repressor Proteins
0
SIM1 protein, human
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2079Subventions
Organisme : NHLBI NIH HHS
ID : R21 HL087858
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL063772
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL097165
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000127
Pays : United States
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