Reduced resilience of brain gray matter networks in idiopathic generalized epilepsy: A graph-theoretical analysis.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
04
04
2018
accepted:
05
02
2019
entrez:
16
2
2019
pubmed:
16
2
2019
medline:
19
11
2019
Statut:
epublish
Résumé
The pathophysiology of idiopathic generalized epilepsy (IGE) is still unclear, but graph theory may help to understand it. Here, we examined the graph-theoretical findings of the gray matter network in IGE using anatomical covariance methods. We recruited 33 patients with IGE and 35 age- and sex-matched healthy controls. Gray matter images were obtained by 3.0-T 3D T1-weighted MRI and were normalized using the voxel-based morphometry tools of Statistical Parametric Mapping 12. The normalized images were subjected to graph-theoretical group comparison using the Graph Analysis Toolbox with two different parcellation schemes. Initially, we used the Automated Anatomical Labeling template, whereas the Hammers Adult atlas was used for the second analysis. The resilience analyses revealed significantly reduced resilience of the IGE gray matter networks to both random failure and targeted attack. No significant between-group differences were found in global network measures, including the clustering coefficient and characteristic path length. The IGE group showed several changes in regional clustering, including an increase mainly in wide areas of the bilateral frontal lobes. The second analysis with another region of interest (ROI) parcellation generated the same results in resilience and global network measures, but the regional clustering results differed between the two parcellation schemes. These results may reflect the potentially weak network organization in IGE. Our findings contribute to the accumulation of knowledge on IGE.
Identifiants
pubmed: 30768622
doi: 10.1371/journal.pone.0212494
pii: PONE-D-18-10100
pmc: PMC6377139
doi:
Banques de données
figshare
['10.6084/m9.figshare.6852812']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0212494Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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