The protective effects of the antioxidant N-acetylcysteine (NAC) against oxidative stress-associated apoptosis evoked by the organophosphorus insecticide malathion in normal human astrocytes.
Acetylcysteine
/ pharmacology
Antioxidants
/ pharmacology
Apoptosis
/ drug effects
Astrocytes
/ drug effects
Cell Survival
/ drug effects
Cytoprotection
/ drug effects
Dose-Response Relationship, Drug
Humans
Insecticides
/ toxicity
Malathion
/ toxicity
Organophosphorus Compounds
/ toxicity
Oxidative Stress
/ drug effects
Apoptosis
Astrocytes
Malathion
N-acetylcysteine (NAC)
Neurotoxicity
Oxidative stress
Journal
Toxicology
ISSN: 1879-3185
Titre abrégé: Toxicology
Pays: Ireland
ID NLM: 0361055
Informations de publication
Date de publication:
01 04 2019
01 04 2019
Historique:
received:
08
12
2018
revised:
23
01
2019
accepted:
09
02
2019
pubmed:
16
2
2019
medline:
15
1
2020
entrez:
16
2
2019
Statut:
ppublish
Résumé
Malathion is one of the most widely used organophosphorus insecticides in agriculture. However, malathion may be involved in the etiology of human brain dysfunction. Induction of ROS has been proposed as a mechanism of malathion-induced poisoning cases, but there are few data regarding the effects of malathion on oxidative stress-associated neurotoxicity in human glial cells. The aim was to explore the mechanism underlying effects of malathion on neurotoxicity in Gibco
Identifiants
pubmed: 30769050
pii: S0300-483X(18)30677-2
doi: 10.1016/j.tox.2019.02.004
pii:
doi:
Substances chimiques
Antioxidants
0
Insecticides
0
Organophosphorus Compounds
0
Malathion
U5N7SU872W
Acetylcysteine
WYQ7N0BPYC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-14Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.