From Human Cytogenetics to Human Chromosomics.
chromosomes
chromosomics
cytogenetics
epigenetics
interphase-architecture
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Feb 2019
14 Feb 2019
Historique:
received:
10
01
2019
revised:
30
01
2019
accepted:
12
02
2019
entrez:
17
2
2019
pubmed:
17
2
2019
medline:
5
6
2019
Statut:
epublish
Résumé
The concept of "chromosomics" was introduced by Prof. Uwe Claussen in 2005. Herein, the growing insights into human chromosome structure finally lead to a "chromosomic view" of the three-dimensional constitution and plasticity of genes in interphase nuclei are discussed. This review is dedicated to the memory of Prof. Uwe Claussen (30 April 1945⁻20 July 2008). Chromosomics is the study of chromosomes, their three-dimensional positioning in the interphase nucleus, the consequences from plasticity of chromosomal subregions and gene interactions, the influence of chromatin-modification-mediated events on cells, and even individuals, evolution, and disease. Progress achieved in recent years is summarized, including the detection of chromosome-chromosome-interactions which, if damaged, lead to malfunction and disease. However, chromosomics in the Human Genetics field is not progressing presently, as research interest has shifted from single cell to high throughput, genomic approaches. Chromosomics and its impact were predicted correctly in 2005 by Prof. Claussen. Although some progress was achieved, present reconsiderations of the role of the chromosome and the single cell in Human Genetic research are urgently necessary.
Sections du résumé
BACKGROUND
BACKGROUND
The concept of "chromosomics" was introduced by Prof. Uwe Claussen in 2005. Herein, the growing insights into human chromosome structure finally lead to a "chromosomic view" of the three-dimensional constitution and plasticity of genes in interphase nuclei are discussed. This review is dedicated to the memory of Prof. Uwe Claussen (30 April 1945⁻20 July 2008).
RECENT FINDINGS
RESULTS
Chromosomics is the study of chromosomes, their three-dimensional positioning in the interphase nucleus, the consequences from plasticity of chromosomal subregions and gene interactions, the influence of chromatin-modification-mediated events on cells, and even individuals, evolution, and disease. Progress achieved in recent years is summarized, including the detection of chromosome-chromosome-interactions which, if damaged, lead to malfunction and disease. However, chromosomics in the Human Genetics field is not progressing presently, as research interest has shifted from single cell to high throughput, genomic approaches.
CONCLUSION
CONCLUSIONS
Chromosomics and its impact were predicted correctly in 2005 by Prof. Claussen. Although some progress was achieved, present reconsiderations of the role of the chromosome and the single cell in Human Genetic research are urgently necessary.
Identifiants
pubmed: 30769866
pii: ijms20040826
doi: 10.3390/ijms20040826
pmc: PMC6413437
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Science. 1988 Dec 23;242(4886):1687-91
pubmed: 3201257
Hum Mol Genet. 2003 Oct 15;12(20):2723-32
pubmed: 12944418
Genomics. 1991 Jul;10(3):786-91
pubmed: 1909684
Comb Chem High Throughput Screen. 2002 Dec;5(8):651-62
pubmed: 12470262
Am J Hum Genet. 1981 Mar;33(2):243-51
pubmed: 6163355
Curr Opin Genet Dev. 2016 Feb;36:1-7
pubmed: 26855137
Hum Genet. 1990 May;84(6):507-11
pubmed: 2186996
Nat Rev Mol Cell Biol. 2016 Dec;17(12):743-755
pubmed: 27580841
Cell. 2018 Jul 26;174(3):758-769.e9
pubmed: 30033370
Leuk Res. 2015 Dec;39(12):1414-20
pubmed: 26423235
Cold Spring Harb Symp Quant Biol. 2015;80:83-91
pubmed: 26801160
Mol Cytogenet. 2016 Jan 22;9:5
pubmed: 26807150
Philos Trans R Soc Lond B Biol Sci. 2017 Nov 5;372(1733):
pubmed: 28947656
Science. 1976 Jan 16;191(4223):185-7
pubmed: 942798
Cytogenet Genome Res. 2003;103(1-2):14-6
pubmed: 15004457
Eur J Hum Genet. 2017 May;25(5):515-519
pubmed: 28272535
OMICS. 2005 Winter;9(4):301-33
pubmed: 16402891
Cell Mol Life Sci. 2003 May;60(5):979-90
pubmed: 12827285
Cell. 2009 Apr 17;137(2):356-68
pubmed: 19379699
Cell Biol Int. 2004;28(11):755-64
pubmed: 15563397
Biochemistry (Mosc). 2018 Apr;83(4):313-325
pubmed: 29626919
Oncogene. 2010 May 6;29(18):2659-71
pubmed: 20154723
Am J Med Genet A. 2006 Mar 1;140(5):442-52
pubmed: 16470732
Exp Cell Res. 1966 Mar;41(3):483-91
pubmed: 4952038
Science. 1921 May 27;53(1378):503-4
pubmed: 17839040
J Vis Exp. 2012 Feb 06;(60):
pubmed: 22331009
Anticancer Res. 1985 Jul-Aug;5(4):411-3
pubmed: 3898996
J Cell Biochem. 2007 Dec 1;102(5):1067-75
pubmed: 17786936
Mol Cancer. 2014 Sep 12;13:214
pubmed: 25216853
Exp Cell Res. 1970 Oct;62(2):490-2
pubmed: 5495462
Science. 1910 Jul 22;32(812):120-2
pubmed: 17759620
Cytogenet Cell Genet. 1994;66(2):120-5
pubmed: 8287683
Biochim Biophys Acta. 2008 Jan;1779(1):3-16
pubmed: 18078840
Int J Mol Med. 2002 Apr;9(4):359-61
pubmed: 11891527
J Cell Sci. 2000 May;113 ( Pt 9):1565-76
pubmed: 10751148
Mol Cytogenet. 2008 Apr 29;1:9
pubmed: 18471270
Genes Chromosomes Cancer. 2006 Jun;45(6):602-7
pubmed: 16518846
Int J Mol Med. 2009 Sep;24(3):335-41
pubmed: 19639225
Geburtshilfe Frauenheilkd. 1994 Aug;54(8):460-7
pubmed: 7982551
Hum Genet. 1980;54(2):277-8
pubmed: 7390497
Curr Genomics. 2010 Sep;11(6):426-31
pubmed: 21358987
Mutat Res. 2002 Jan 29;499(1):13-25
pubmed: 11804602
Nat Commun. 2018 Dec 5;9(1):5180
pubmed: 30518921
Cytogenet Cell Genet. 1997;79(1-2):162-6
pubmed: 9533040
Cytogenet Cell Genet. 1997;76(3-4):167-71
pubmed: 9186512
Cytogenet Cell Genet. 2000;90(1-2):13-21
pubmed: 11060439
Int J Oncol. 2010 Apr;36(4):929-40
pubmed: 20198338
Hum Genet. 1990 May;84(6):512-6
pubmed: 2159949
Curr Opin Biotechnol. 2002 Oct;13(5):517-21
pubmed: 12459347
Eur J Hum Genet. 2014 Mar;22(3):338-43
pubmed: 23860044
Hum Mol Genet. 2004 Nov 1;13(21):2547-55
pubmed: 15385437
Hereditas. 1967;57(1):1-22
pubmed: 4295214
J Histochem Cytochem. 2005 Mar;53(3):365-6
pubmed: 15750021
Cytogenet Genome Res. 2005;111(2):101-6
pubmed: 16103649
J Histochem Cytochem. 2002 Dec;50(12):1697-8
pubmed: 12486094
Ai Zheng. 2003 May;22(5):449-51
pubmed: 12753700
Science. 2004 Jul 23;305(5683):525-8
pubmed: 15273396
Cytogenet Genome Res. 2004;105(1):25-8
pubmed: 15218254
Methods. 2017 Jul 1;123:33-46
pubmed: 28323041
Science. 1964 May 15;144(3620):809-15
pubmed: 14149391
Otolaryngol Pol. 2000;54(3):291-5
pubmed: 10917055
Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a003889
pubmed: 20300217
Mol Cytogenet. 2016 Apr 27;9:36
pubmed: 27123045
J Cell Sci. 2008 Jan;121 Suppl 1:1-84
pubmed: 18089652
Curr Biol. 2000 Feb 10;10(3):149-52
pubmed: 10679329
Clin Genet. 1992 Feb;41(2):100-4
pubmed: 1544209
Mol Cytogenet. 2015 Mar 20;8:19
pubmed: 25810762
Curr Opin Nephrol Hypertens. 2005 Mar;14(2):133-9
pubmed: 15687839
Mol Cytogenet. 2008 Nov 14;1:25
pubmed: 19014589
Mutat Res. 2002 Jul 25;504(1-2):37-45
pubmed: 12106644
Balkan J Med Genet. 2011 Dec;14(2):13-6
pubmed: 24052707
Acta Paediatr Jpn. 1992 Apr;34(2):166-8
pubmed: 1621521
Hum Mol Genet. 2013 Dec 15;22(24):4901-13
pubmed: 23863462
Int J Mol Med. 2008 Feb;21(2):189-200
pubmed: 18204785
Cytogenet Cell Genet. 1999;84(3-4):156-60
pubmed: 10393418
Mol Cytogenet. 2013 May 21;6(1):20
pubmed: 23693023
Cytogenet Cell Genet. 2001;93(3-4):155-61
pubmed: 11528105
Mol Cytogenet. 2012 Mar 14;5:15
pubmed: 22413994
Nature. 1953 May 30;171(4361):964-7
pubmed: 13063483
Urol Int. 1976;31(3):239-45
pubmed: 960305
Syst Biol Reprod Med. 2015 Jan;61(1):32-6
pubmed: 25374326
Mol Cytogenet. 2009 Jan 26;2:4
pubmed: 19171032
Mol Cytogenet. 2010 Mar 29;3:8
pubmed: 20350319
Mol Biol (Mosk). 2007 May-Jun;41(3):408-22
pubmed: 17685220
Cytogenet Genome Res. 2002;97(1-2):43-50
pubmed: 12438737
Genomics. 2013 Oct;102(4):288-95
pubmed: 23648727
Int J Mol Sci. 2012;13(9):11974-11999
pubmed: 23109895
Environ Health Perspect. 2004 May;112(7):A396-7
pubmed: 15159211
Nat Genet. 2004 Sep;36(9):949-51
pubmed: 15286789
Heliyon. 2015 Nov 24;1(3):e00042
pubmed: 27441227
Cell. 1991 Feb 22;64(4):761-6
pubmed: 1997205
Proc Natl Acad Sci U S A. 1962 Feb;48(2):190-8
pubmed: 16590919
Mutat Res. 1996 Nov;366(2):97-116
pubmed: 9001577
Mamm Genome. 1992;3(2):101-5
pubmed: 1617213
Genetika. 2010 Sep;46(9):1159-63
pubmed: 21058510
Nature. 2012 Jan 18;482(7383):53-8
pubmed: 22258507
Am J Hum Genet. 2002 Nov;71(5):1051-9
pubmed: 12370837
Cytogenet Cell Genet. 2001;95(1-2):12-6
pubmed: 11978963
Cytogenet Genome Res. 2007;119(1-2):2-8
pubmed: 18160774
Methods Mol Biol. 2018;1675:233-246
pubmed: 29052195
EMBO J. 2018 Aug 1;37(15):
pubmed: 29921581
Nature. 1953 Apr 25;171(4356):737-8
pubmed: 13054692
Mol Cytogenet. 2010 Nov 09;3:22
pubmed: 21062444
Cytogenet Genome Res. 2002;98(2-3):136-46
pubmed: 12697995
Mol Cytogenet. 2014 Nov 19;7(1):79
pubmed: 25435911
Hum Genet. 2001 Mar;108(3):199-204
pubmed: 11354630
Chromosoma. 2017 Mar;126(2):223-244
pubmed: 26921073
Nature. 1989 Mar 23;338(6213):348-50
pubmed: 2784197
Genetics. 2002 Jan;160(1):1-4
pubmed: 11805039
Cell. 2011 Jan 7;144(1):9-10
pubmed: 21215363
Annu Rev Biochem. 2003;72:573-608
pubmed: 14527325
Cytogenet Genome Res. 2015;145(1):42-9
pubmed: 25926034
Expert Rev Mol Diagn. 2015 Apr;15(4):517-26
pubmed: 25664836
Am J Med Genet A. 2003 Apr 30;118A(3):235-40
pubmed: 12673653
Curr Biol. 1998 Apr 23;8(9):R321-4
pubmed: 9560332
Curr Mol Med. 2002 May;2(3):283-97
pubmed: 12041731
Arch Pathol Lab Med. 2004 Dec;128(12):1337-45
pubmed: 15578876
Int J Mol Med. 2002 Apr;9(4):335-9
pubmed: 11891523
Trends Cell Biol. 2014 May;24(5):321-7
pubmed: 24361091