Synthesis and evaluation of

3-Iodobenzylguanidine / chemical synthesis Animals Cell Line, Tumor Chemistry Techniques, Synthetic Drug Stability Humans Norepinephrine Plasma Membrane Transport Proteins / metabolism Radiochemistry Rats Rats, Wistar Technetium / chemistry Tissue Distribution
(99m)Tc-carbonyl Neuroendocrine tumor Norepinephrine transporter [(123/131)I]mIBG

Journal

Nuclear medicine and biology
ISSN: 1872-9614
Titre abrégé: Nucl Med Biol
Pays: United States
ID NLM: 9304420

Informations de publication

Date de publication:
Historique:
received: 02 08 2018
revised: 02 01 2019
accepted: 03 01 2019
pubmed: 17 2 2019
medline: 1 5 2020
entrez: 17 2 2019
Statut: ppublish

Résumé

meta-[ Two different precursors, xylylenediamine and 1,3-bis(chloromethyl)benzene, were synthetically modified to yield meta-functionalized benzylguanidine derivatives bearing iminodiacetate (IDA) and aminoethylglycine (AEG) tridentate chelating moieties, respectively. These ligands were labeled with technetium-99m via [ Cell uptake studies with the radiolabeled complexes in SK-N-SH neuroblastoma cell lines revealed reduced uptake in the cells (<1% of incubated radioactivity/10 Tridentate [

Identifiants

DOI: 10.1016/j.nucmedbio.2019.01.001 PMID: 30770228
pubmed: 30770228
pii: S0969-8051(18)30249-X
doi: 10.1016/j.nucmedbio.2019.01.001
pii:
doi:

Substances chimiques

Norepinephrine Plasma Membrane Transport Proteins 0
3-Iodobenzylguanidine 35MRW7B4AD
Technetium 7440-26-8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

49-57

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Soumen Das (S)

Radiopharmaceuticals Program, Board of Radiation and Isotope Technology (BRIT), Navi Mumbai 400703, India; Homi Bhabha National Institute (HBNI), Anushaktinagar, Mumbai 400094, India.

Navin Sakhare (N)

Radiopharmaceuticals Program, Board of Radiation and Isotope Technology (BRIT), Navi Mumbai 400703, India.

Anupam Mathur (A)

Radiopharmaceuticals Program, Board of Radiation and Isotope Technology (BRIT), Navi Mumbai 400703, India. Electronic address: amathur@britatom.gov.in.

Madhava B Mallia (MB)

Homi Bhabha National Institute (HBNI), Anushaktinagar, Mumbai 400094, India; Radiopharmaceutical Division, Bhabha Atomic Research Centre (BARC), Trombay, Mumbai 400085, India.

Shubhangi Mirapurkar (S)

Radiopharmaceuticals Program, Board of Radiation and Isotope Technology (BRIT), Navi Mumbai 400703, India.

M Sheela (M)

Radiopharmaceuticals Program, Board of Radiation and Isotope Technology (BRIT), Navi Mumbai 400703, India.

H D Sarma (HD)

Radiation Biology and Health Science Division, Bhabha Atomic Research Centre (BARC), Trombay, Mumbai 400085, India.

S S Sachdev (SS)

Radiopharmaceuticals Program, Board of Radiation and Isotope Technology (BRIT), Navi Mumbai 400703, India.

Ashutosh Dash (A)

Homi Bhabha National Institute (HBNI), Anushaktinagar, Mumbai 400094, India; Radiopharmaceutical Division, Bhabha Atomic Research Centre (BARC), Trombay, Mumbai 400085, India.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures iodés › Iodobenzènes › 3-Iodobenzyl-guanidine › Synthesis and evaluation of
questionsmedicales.fr › Eucaryotes › Animaux › Synthesis and evaluation of
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Synthesis and evaluation of
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Synthesis and evaluation of
questionsmedicales.fr › Techniques d'investigation › Stabilité de médicament › Synthesis and evaluation of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis and evaluation of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la norépinéphrine › Synthesis and evaluation of
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Chimie physique › Radiochimie › Synthesis and evaluation of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Synthesis and evaluation of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Synthesis and evaluation of
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Technétium › Synthesis and evaluation of
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Synthesis and evaluation of