Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank.
Adult
Aged
Apolipoproteins E
/ genetics
Biological Specimen Banks
Delirium
/ epidemiology
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Mendelian Randomization Analysis
Middle Aged
Polymorphism, Single Nucleotide
Prospective Studies
United Kingdom
Vitamin D
/ genetics
White People
/ genetics
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
19 03 2019
19 03 2019
Historique:
received:
15
05
2018
accepted:
14
11
2018
pubmed:
17
2
2019
medline:
18
12
2019
entrez:
17
2
2019
Statut:
ppublish
Résumé
To estimate effects of vitamin D levels on incident delirium hospital admissions using inherited genetic variants in mendelian randomization models, which minimize confounding and exclude reverse causation. Longitudinal analysis using the UK Biobank, community-based, volunteer cohort (2006-2010) with incident hospital-diagnosed delirium (ICD-10 F05) ascertained during ≤9.9 years of follow-up of hospitalization records (to early 2016). We included volunteers of European descent aged 60-plus years by end of follow-up. We used single-nucleotide polymorphisms previously shown to increase circulating vitamin D levels, and Of 313,121 participants included, 544 were hospitalized with delirium during follow-up. Vitamin D variants were protective for incident delirium: hazard ratio = 0.74 per 10 nmol/L (95% confidence interval 0.62-0.87, In a large community-based cohort, there is genetic evidence supporting a causal role for vitamin D levels in incident delirium. Trials of correction of low vitamin D levels in the prevention of delirium are needed.
Identifiants
pubmed: 30770424
pii: WNL.0000000000007136
doi: 10.1212/WNL.0000000000007136
pmc: PMC6511096
doi:
Substances chimiques
Apolipoproteins E
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1387-e1394Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Department of Health
ID : PB-PG-1215-20022
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
Références
Nature. 2018 Jun;558(7708):73-79
pubmed: 29875488
Proc Nutr Soc. 2018 May;77(2):124-134
pubmed: 29233204
J Steroid Biochem Mol Biol. 2009 Jul;115(3-5):91-7
pubmed: 19500727
Psychiatr Genet. 2016 Apr;26(2):53-9
pubmed: 26901792
Aging (Albany NY). 2017 Dec 6;9(12):2504-2520
pubmed: 29227965
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Nat Commun. 2016 Jan 21;7:10023
pubmed: 26831199
Sci Rep. 2017 Oct 16;7(1):13230
pubmed: 29038561
J Am Geriatr Soc. 2017 Oct;65(10):2161-2168
pubmed: 28758188
Nat Commun. 2018 Aug 15;9(1):3268
pubmed: 30111768
Int J Epidemiol. 2015 Apr;44(2):512-25
pubmed: 26050253
N Engl J Med. 2006 Mar 16;354(11):1157-65
pubmed: 16540616
Inflamm Res. 2014 Oct;63(10):803-19
pubmed: 25048990
Nucleic Acids Res. 2017 Jan 4;45(D1):D896-D901
pubmed: 27899670
PLoS Genet. 2017 Oct 5;13(10):e1006944
pubmed: 28981501
FASEB J. 2015 Jun;29(6):2207-22
pubmed: 25713056
PLoS Med. 2013;10(2):e1001383
pubmed: 23393431
PLoS Genet. 2013;9(9):e1003796
pubmed: 24068962
Semin Clin Neuropsychiatry. 2000 Apr;5(2):125-31
pubmed: 10837101
PLoS Med. 2015 Mar 31;12(3):e1001779
pubmed: 25826379
Nat Commun. 2018 Jan 17;9(1):260
pubmed: 29343764
J Inflamm Res. 2014 May 29;7:69-87
pubmed: 24971027
Br J Nutr. 2015 Jun 14;113(11):1753-60
pubmed: 26067807
Bioinformatics. 2010 Nov 15;26(22):2867-73
pubmed: 20926424
BMJ. 2017 Dec 6;359:j5375
pubmed: 29212772
Arch Intern Med. 2002 Feb 25;162(4):457-63
pubmed: 11863480
Am J Hum Genet. 2017 Aug 3;101(2):227-238
pubmed: 28757204