Berberine as a potential autophagy modulator.
autophagy
berberine
drug-resistant
pharmacognosy
programmed cell death
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
revised:
21
01
2019
received:
07
12
2018
accepted:
24
01
2019
pubmed:
17
2
2019
medline:
17
2
2019
entrez:
17
2
2019
Statut:
ppublish
Résumé
Today, pharmacognosy is considered a valuable science in the prevention and treatment of diseases. Among herbals, Berberine is an isoquinoline alkaloid found in the Berberis species. Surprisingly, it shows antimicrobial, antiviral, antidiarrheal, antipyretic, and anti-inflammatory potential. Furthermore, it diminishes drug resistance in cancer therapy and enhances tumor suppression in part through autophagy and cell cycle arrest mechanisms. In the present review, we discuss the effect of berberine on diverse cellular pathways and describe how berberine acts as an autophagy modulator to adjust physiologic and pathologic conditions and diminishes drug resistance in cancer therapy.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
14914-14926Informations de copyright
© 2019 Wiley Periodicals, Inc.