Eph/ephrin signalling in the development and function of the mammalian cochlea.
Cochlea
Development
Eph receptor
Ephrin
Hearing
Inner ear
Journal
Developmental biology
ISSN: 1095-564X
Titre abrégé: Dev Biol
Pays: United States
ID NLM: 0372762
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
received:
09
01
2019
revised:
10
02
2019
accepted:
11
02
2019
pubmed:
17
2
2019
medline:
19
12
2019
entrez:
17
2
2019
Statut:
ppublish
Résumé
In mammals, the functional development of the cochlea requires the tight regulation of multiple molecules and signalling pathways including fibroblast growth factors, bone morphogenetic proteins, Wnt and Notch signalling pathways. Over the last decade, the Eph/ephrin system also emerged as a key player of the development and function of the mammalian cochlea. In this review, we discuss the recent advances on the role of Eph/ephrin signalling in patterning the cochlear sensory epithelium and the complex innervation of mechanosensory hair cells by spiral ganglion neurons. Finally, we address the issue of a syndromic form of hearing loss caused by a deficient member of the Eph/ephrin family.
Identifiants
pubmed: 30771305
pii: S0012-1606(19)30014-4
doi: 10.1016/j.ydbio.2019.02.004
pii:
doi:
Substances chimiques
Ephrins
0
Receptors, Eph Family
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-40Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.