Natural and synthetic nanopores directing osteogenic differentiation of human stem cells.
Adult stem cells
Collagen
Nanopores
Osteogenic differentiation
SiO(2) nanocomposite
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
13
08
2018
revised:
29
01
2019
accepted:
30
01
2019
pubmed:
17
2
2019
medline:
22
11
2019
entrez:
17
2
2019
Statut:
ppublish
Résumé
Bone regeneration is a highly orchestrated process crucial for endogenous healing procedures after accidents, infections or tumor therapy. Changes in surface nanotopography are known to directly affect the formation of osteogenic cell types, although no direct linkage to the endogenous nanotopography of bone was described so far. Here we show the presence of pores of 31.93 ± 0.97 nm diameter on the surface of collagen type I fibers, the organic component of bone, and demonstrate these pores to be sufficient to induce osteogenic differentiation of adult human stem cells. We further applied SiO
Identifiants
pubmed: 30771503
pii: S1549-9634(19)30030-9
doi: 10.1016/j.nano.2019.01.018
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Collagen Type I
0
Silicon Dioxide
7631-86-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
319-328Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.