Changes in blood pressure associated with lead, manganese, and selenium in a Bangladeshi cohort.
Bangladesh
Blood pressure
Essential metals
Pulse pressure
Toxic metals
Journal
Environmental pollution (Barking, Essex : 1987)
ISSN: 1873-6424
Titre abrégé: Environ Pollut
Pays: England
ID NLM: 8804476
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
13
09
2018
revised:
07
01
2019
accepted:
31
01
2019
pubmed:
17
2
2019
medline:
12
7
2019
entrez:
17
2
2019
Statut:
ppublish
Résumé
Heavy metal contamination is widespread in Bangladesh. Previous studies have observed lead increases blood pressure over time. However, the role of other metal contaminants and essential micronutrients, which could also adversely affect blood pressure or act as protective factors, is understudied. We therefore evaluated the associations of lead, manganese, and selenium with blood and pulse pressure trajectories. We prospectively followed placebo-assigned participants nested within a randomized trial for the prevention of arsenic-related skin cancer (n = 255). Blood lead, manganese, and selenium were measured at baseline; blood pressure was measured at baseline and at 3 biennial follow-up examinations. Mixed-effect linear regression models were used to estimate associations with average annual changes in systolic, diastolic, and pulse pressure. In models simultaneously adjusted for baseline blood lead, manganese, and selenium concentrations in addition to other potential confounders, lead was linearly associated with increases in systolic blood pressure, but not with diastolic blood pressure or pulse pressure. A non-linear association was observed for manganese, such that mid-range concentrations were associated with decreases in systolic, diastolic, and pulse pressure. Baseline selenium concentrations in the highest quartile were also associated with longitudinal decreases in both systolic and diastolic blood pressure, while null associations were observed with pulse pressure. In exploratory analyses, the combination of mid-range manganese and high selenium concentrations completely offset lead-associated increases in blood and pulse pressure. The results indicate a direct, linear association of lead exposure with systolic blood pressure, and manganese and selenium exposures within certain ranges may have a blood pressure-lowering effect in this population.
Sections du résumé
BACKGROUND
BACKGROUND
Heavy metal contamination is widespread in Bangladesh. Previous studies have observed lead increases blood pressure over time. However, the role of other metal contaminants and essential micronutrients, which could also adversely affect blood pressure or act as protective factors, is understudied.
OBJECTIVES
OBJECTIVE
We therefore evaluated the associations of lead, manganese, and selenium with blood and pulse pressure trajectories.
METHODS
METHODS
We prospectively followed placebo-assigned participants nested within a randomized trial for the prevention of arsenic-related skin cancer (n = 255). Blood lead, manganese, and selenium were measured at baseline; blood pressure was measured at baseline and at 3 biennial follow-up examinations. Mixed-effect linear regression models were used to estimate associations with average annual changes in systolic, diastolic, and pulse pressure.
RESULTS
RESULTS
In models simultaneously adjusted for baseline blood lead, manganese, and selenium concentrations in addition to other potential confounders, lead was linearly associated with increases in systolic blood pressure, but not with diastolic blood pressure or pulse pressure. A non-linear association was observed for manganese, such that mid-range concentrations were associated with decreases in systolic, diastolic, and pulse pressure. Baseline selenium concentrations in the highest quartile were also associated with longitudinal decreases in both systolic and diastolic blood pressure, while null associations were observed with pulse pressure. In exploratory analyses, the combination of mid-range manganese and high selenium concentrations completely offset lead-associated increases in blood and pulse pressure.
CONCLUSIONS
CONCLUSIONS
The results indicate a direct, linear association of lead exposure with systolic blood pressure, and manganese and selenium exposures within certain ranges may have a blood pressure-lowering effect in this population.
Identifiants
pubmed: 30771745
pii: S0269-7491(18)34181-2
doi: 10.1016/j.envpol.2019.01.129
pmc: PMC6517081
mid: NIHMS1521601
pii:
doi:
Substances chimiques
Ions
0
Metals, Heavy
0
Manganese
42Z2K6ZL8P
Selenium
H6241UJ22B
Arsenic
N712M78A8G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
28-35Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES010126
Pays : United States
Organisme : NIEHS NIH HHS
ID : R24 ES028532
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES024423
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES010349
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL125294
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA107431
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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