Impact of Toll-Like Receptor 4 Signaling in Necrotizing Enterocolitis: The State of the Science.

Enterocolitis, Necrotizing / immunology Humans Infant, Newborn Infant, Premature Inflammation / immunology Intestinal Mucosa / immunology Toll-Like Receptor 4 / immunology
Epithelial cells Inflammation Necrotizing enterocolitis TLR4

Journal

Clinics in perinatology
ISSN: 1557-9840
Titre abrégé: Clin Perinatol
Pays: United States
ID NLM: 7501306

Informations de publication

Date de publication:
03 2019
Historique:
entrez: 18 2 2019
pubmed: 18 2 2019
medline: 19 6 2019
Statut: ppublish

Résumé

Necrotizing enterocolitis (NEC) remains a leading cause of preterm infant mortality. NEC is multifactorial and believed a consequence of intestinal immaturity, microbial dysbiosis, and an exuberant inflammatory response. Over the past decade, exaggerated Toll-like receptor 4 (TLR4) activity in the immature intestine of preterm neonates emerged as an inciting event preceding NEC. Increased TLR4 signaling in epithelial cells results in the initiation of an uncontrolled immune response and destruction of the mucosal barrier. This article discusses the state of the science of the molecular mechanisms involved in TLR4-mediated inflammation during NEC and the development of new therapeutic strategies to prevent NEC.

Identifiants

DOI: 10.1016/j.clp.2018.09.007 PMID: 30771815 PMC: PMC6383801
pubmed: 30771815
pii: S0095-5108(18)31428-3
doi: 10.1016/j.clp.2018.09.007
pmc: PMC6383801
mid: NIHMS1508449
pii:
doi:

Substances chimiques

TLR4 protein, human 0
Toll-Like Receptor 4 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

145-157

Subventions

Organisme : NIDDK NIH HHS
ID : K08 DK101608
Pays : United States
Organisme : NIDDK NIH HHS
ID : R03 DK111473
Pays : United States

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

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Auteurs

Belgacem Mihi (B)

Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8208, St Louis, MO 63110, USA.

Misty Good (M)

Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8208, St Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8208, St Louis, MO 63110, USA. Electronic address: mistygood@wustl.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Entérocolite › Entérocolite nécrosante › Impact of Toll-Like Receptor 4 Signaling in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Impact of Toll-Like Receptor 4 Signaling in...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Impact of Toll-Like Receptor 4 Signaling in...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Prématuré › Impact of Toll-Like Receptor 4 Signaling in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Impact of Toll-Like Receptor 4 Signaling in...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Impact of Toll-Like Receptor 4 Signaling in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-4 › Impact of Toll-Like Receptor 4 Signaling in...