The risk of extra-ovarian malignancies among women with endometriosis: A systematic literature review and meta-analysis.
Breast cancer
Cervical cancer
Endometrial cancer
Endometriosis
Melanoma
Thyroid cancer
Journal
Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
30
09
2018
revised:
29
12
2018
accepted:
30
12
2018
entrez:
18
2
2019
pubmed:
18
2
2019
medline:
11
4
2019
Statut:
ppublish
Résumé
We conducted a meta-analysis of studies reporting on the risk of extra-ovarian malignancies among women with endometriosis. Summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We explored causes of between-studies heterogeneity and assessed the presence of publication bias. We included 32 studies published between 1989 and 2018. We found an increased risk of endometrial (SRR 1.38, 95%CI 1.10-1.74) and thyroid cancer (SRR 1.38, 95%CI 1.17-1.63), and inverse association with cervical cancer (SRR 0.78, 95%CI 0.60-0.95). No association emerged for breast cancer (SRR 1.04, 95%CI 0.99-1.09) and melanoma (SRR 1.31, 95%CI 0.86-1.96). Between-study heterogeneity was large for breast and endometrial cancer and melanoma. Associations were generally stronger in case-control, cross-sectional, and cohort studies with internal control group, compared to cohort studies with external control group. No indication for publication bias was found. Our conclusions need to be confirmed in properly designed cohort studies with clinical confirmation of endometriosis.
Identifiants
pubmed: 30771877
pii: S1040-8428(18)30460-8
doi: 10.1016/j.critrevonc.2018.12.009
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
72-81Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.