A SUV39H1-low chromatin state characterises and promotes migratory properties of cervical cancer cells.
Cell migration
Cervical cancer
Chromatin
Genomics
Intratumoural heterogeneity
SUV39H1
Journal
Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226
Informations de publication
Date de publication:
15 05 2019
15 05 2019
Historique:
received:
25
09
2018
revised:
11
02
2019
accepted:
13
02
2019
pubmed:
18
2
2019
medline:
27
5
2020
entrez:
18
2
2019
Statut:
ppublish
Résumé
Metastatic progression is a major cause of mortality in cervical cancers, but factors regulating migratory and pre-metastatic cell populations remain poorly understood. Here, we sought to assess whether a SUV39H1-low chromatin state promotes migratory cell populations in cervical cancers, using meta-analysis of data from The Cancer Genome Atlas (TCGA), immunohistochemistry, genomics and functional assays. Cervical cancer cells sorted based on migratory ability in vitro have low levels of SUV39H1 protein, and SUV39H1 knockdown in vitro enhanced cervical cancer cell migration. Further, TCGA SUV39H1-low tumours correlated with poor clinical outcomes and showed gene expression signatures of cell migration. SUV39H1 expression was examined within biopsies, and SUV39H1
Identifiants
pubmed: 30772380
pii: S0014-4827(18)30986-8
doi: 10.1016/j.yexcr.2019.02.010
pii:
doi:
Substances chimiques
Chromatin
0
Histones
0
Repressor Proteins
0
SUV39H1 protein, human
EC 2.1.1.
Methyltransferases
EC 2.1.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
206-216Subventions
Organisme : Medical Research Council
ID : G0701175
Pays : United Kingdom
Organisme : DBT-Wellcome Trust India Alliance
ID : IA/E/14/1/501773
Pays : India
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.