Molecular diagnosis and enrichment culture identified a septic pseudoarthrosis due to an infection with Erysipelatoclostridium ramosum.

Adult Clostridium / isolation & purification Female Femur Humans Pseudarthrosis / etiology
Bacterial genomics Bone insufficiency Clostridium ramosum Erysipelatoclostridium ramosum Graft resorption Pseudoarthrosis Taxogenomics

Journal

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933

Informations de publication

Date de publication:
Apr 2019
Historique:
received: 17 01 2019
revised: 06 02 2019
accepted: 08 02 2019
pubmed: 18 2 2019
medline: 14 6 2019
entrez: 18 2 2019
Statut: ppublish

Résumé

We describe here a rare case of septic pseudarthrosis due to Erysipelatoclostridium ramosum in a female young patient. The patient, currently in remission from Ewing's sarcoma treated by a bone resection and allograft combined with chemotherapy, suffered from a chronic femoral pseudarthrosis in a context of bone insufficiency and graft resorption. A broad range 16S PCR followed by sequencing, as well as an enrichment culture of a bone biopsy revealed the presence of E. ramosum, an anaerobic firmicute with a low Gram-positive affinity staining and low GC content, that was further characterized by whole genome sequencing (WGS).

Identifiants

DOI: 10.1016/j.ijid.2019.02.001 PMID: 30772466
pubmed: 30772466
pii: S1201-9712(19)30065-7
doi: 10.1016/j.ijid.2019.02.001
pii:
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

167-169

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Fathiah Zakham (F)

Institute of Microbiology, Lausanne University Hospital and Lausanne University, Switzerland.

Trestan Pillonel (T)

Institute of Microbiology, Lausanne University Hospital and Lausanne University, Switzerland.

Anne-Sophie Brunel (AS)

Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and Lausanne University, Switzerland.

Pierre-Yves Zambelli (PY)

Unité Pédiatrique de Chirurgie Orthopédique et Traumatologique UPCOT, Hôpital de l'Enfance, Lausanne University Hospital, Switzerland.

Gilbert Greub (G)

Institute of Microbiology, Lausanne University Hospital and Lausanne University, Switzerland.

Antony Croxatto (A)

Institute of Microbiology, Lausanne University Hospital and Lausanne University, Switzerland.

Claire Bertelli (C)

Institute of Microbiology, Lausanne University Hospital and Lausanne University, Switzerland. Electronic address: Claire.Bertelli@chuv.ch.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Molecular diagnosis and enrichment culture...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bactéries à Gram positif formant des endospores › Clostridium › Molecular diagnosis and enrichment culture...
questionsmedicales.fr › Appareil locomoteur › Squelette › Os du membre inférieur › Fémur › Molecular diagnosis and enrichment culture...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular diagnosis and enrichment culture...
questionsmedicales.fr › Plaies et blessures › Fractures osseuses › Fractures non consolidées › Pseudarthrose › Molecular diagnosis and enrichment culture...