Candida Tropicalis renal microabscesses in a child with leukemia confirmed using nucleic acid amplification and recovery after prolonged antifungal and corticosteroid treatment.
Abscess
/ drug therapy
Adrenal Cortex Hormones
/ therapeutic use
Antifungal Agents
/ therapeutic use
Candida tropicalis
Candidiasis
/ drug therapy
Child, Preschool
Humans
Kidney Diseases
/ drug therapy
Male
Nucleic Acid Amplification Techniques
/ methods
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ complications
Ultrasonography, Interventional
Candida
Leukemia
Nucleic acid amplification
Polymerase chain reaction
Renal abscess
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
28
11
2018
revised:
01
02
2019
accepted:
08
02
2019
pubmed:
18
2
2019
medline:
14
6
2019
entrez:
18
2
2019
Statut:
ppublish
Résumé
We report the first case of microabscesses detected by polymerase chain reaction (PCR) amplification of nucleic acid from ultrasound-guided aspirated fluid in a three-year old boy with acute lymphoblastic leukemia and febrile neutropenia during induction chemotherapy. Fever persisted despite effective antifungal treatment. The addition of corticosteroid therapy successfully controlled the suspected immune reconstitution inflammatory syndrome (IRIS). This case highlights the utility of PCR and adjunctive corticosteroid in the approach of Candida tropicalis renal microabscesses in leukemic patients undergoing chemotherapy.
Identifiants
pubmed: 30772467
pii: S1201-9712(19)30066-9
doi: 10.1016/j.ijid.2019.02.002
pii:
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Antifungal Agents
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110-113Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.