Whole tissue cervical mapping of HPV infection: Molecular evidence for focal latent HPV infection in humans.
HPV
Humans
Molecular biology
Papillomavirus
Uterine cervical neoplasm
Virus latency
Journal
Papillomavirus research (Amsterdam, Netherlands)
ISSN: 2405-8521
Titre abrégé: Papillomavirus Res
Pays: Netherlands
ID NLM: 101662552
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
06
12
2018
revised:
01
02
2019
accepted:
13
02
2019
pubmed:
18
2
2019
medline:
11
1
2020
entrez:
18
2
2019
Statut:
ppublish
Résumé
In this study, we aimed to provide molecular evidence of HPV latency in humans and discuss potential challenges of conducting studies on latency. We analyzed the entire cervix of two women who underwent hysterectomy unrelated to cervical abnormality. The cervices were sectioned into 242 and 186 sets respectively, and each set was tested separately for HPV using the SPF10-PCR-DEIA-LiPA25 system. To identify whether there was any evidence of transforming or productive infection, we used the biomarkers E4 and P16
Identifiants
pubmed: 30772498
pii: S2405-8521(18)30146-0
doi: 10.1016/j.pvr.2019.02.004
pmc: PMC6389775
pii:
doi:
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-87Subventions
Organisme : Medical Research Council
ID : MC_PC_13050
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S024409/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
Références
Mod Pathol. 2015 Jul;28(7):977-93
pubmed: 25953390
Viruses. 2017 Sep 21;9(10):
pubmed: 28934151
Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1585-94
pubmed: 20530494
J Clin Microbiol. 2006 Sep;44(9):3292-8
pubmed: 16954263
J Clin Microbiol. 1999 Aug;37(8):2508-17
pubmed: 10405393
Br J Cancer. 2017 Nov 7;117(10):1557-1561
pubmed: 28881359
J Clin Invest. 2011 Dec;121(12):4593-9
pubmed: 22133884
Open Virol J. 2012;6:190-7
pubmed: 23341854
J Virol. 2003 Oct;77(19):10186-201
pubmed: 12970404
Lab Invest. 1994 Oct;71(4):604-11
pubmed: 7967515
J Infect Dis. 2013 Jan 15;207(2):272-80
pubmed: 23242540
J Natl Cancer Inst. 2005 Apr 20;97(8):577-86
pubmed: 15840880
Virology. 2011 Jun 5;414(2):153-63
pubmed: 21492895
J Med Virol. 2014 Jun;86(6):975-82
pubmed: 24610211
Am J Surg Pathol. 2015 Nov;39(11):1518-1528
pubmed: 26379150
Cancer Epidemiol Biomarkers Prev. 2014 Jan;23(1):200-8
pubmed: 24130223
Virology. 2012 Feb 20;423(2):195-204
pubmed: 22217391
Clin Sci (Lond). 2006 May;110(5):525-41
pubmed: 16597322
Virology. 2009 Aug 1;390(2):261-7
pubmed: 19497607
Am J Pathol. 1994 Jun;144(6):1167-71
pubmed: 8203458
Virology. 2013 Oct;445(1-2):80-98
pubmed: 24016539
Sex Transm Dis. 2012 Nov;39(11):848-56
pubmed: 23064533
Sci Rep. 2016 Feb 15;6:20847
pubmed: 26875676
Int J STD AIDS. 2016 Jun;27(7):543-53
pubmed: 26002318
Am J Transplant. 2013 Dec;13(12):3202-9
pubmed: 24119294
Am J Transplant. 2017 Jun;17(6):1563-1573
pubmed: 28009475
Am J Clin Pathol. 1991 Feb;95(2):117-24
pubmed: 1846996
J Pathol. 2001 May;194(1):51-8
pubmed: 11329141
Cancer Res. 2012 Dec 1;72(23):6183-90
pubmed: 23019223
Obstet Gynecol. 2000 Sep;96(3):403-9
pubmed: 10960634
Open Virol J. 2012;6:198-203
pubmed: 23341855
J Virol. 2014 Jan;88(1):710-6
pubmed: 24173230
Curr Protoc Microbiol. 2016 May 06;41:14B.7.1-14B.7.20
pubmed: 27153382
PLoS One. 2011;6(9):e24451
pubmed: 21915330
Am J Pathol. 1998 Dec;153(6):1731-9
pubmed: 9846964