Prenatal alcohol exposure and facial morphology in a UK cohort.
Adult
Alcohol Dehydrogenase
/ analysis
Alcohol Drinking
/ adverse effects
Biomarkers
/ analysis
Child
Face
/ abnormalities
Female
Fetal Alcohol Spectrum Disorders
/ etiology
Genotype
Humans
Longitudinal Studies
Male
Maternal Exposure
/ adverse effects
Phenotype
Pregnancy
Pregnancy Complications
/ genetics
Prenatal Exposure Delayed Effects
/ chemically induced
United Kingdom
ALSPAC
Alcohol
Facial morphology
Mendelian randomization
Journal
Drug and alcohol dependence
ISSN: 1879-0046
Titre abrégé: Drug Alcohol Depend
Pays: Ireland
ID NLM: 7513587
Informations de publication
Date de publication:
01 04 2019
01 04 2019
Historique:
received:
15
05
2018
revised:
29
11
2018
accepted:
30
11
2018
pubmed:
18
2
2019
medline:
2
7
2019
entrez:
18
2
2019
Statut:
ppublish
Résumé
High levels of prenatal alcohol exposure are known to cause an array of adverse outcomes including fetal alcohol syndrome (FAS); however, the effects of low to moderate exposure are less-well characterized. Previous findings suggest that differences in normal-range facial morphology may be a marker for alcohol exposure and related adverse effects. In the Avon Longitudinal Study of Parents and Children, we tested for an association between maternal alcohol consumption and six FAS-related facial phenotypes in their offspring, using both self-report questionnaires and the maternal genotype at rs1229984 in ADH1B as measures of maternal alcohol consumption. In both self-reported alcohol consumption (N = 4233) and rs1229984 genotype (N = 3139) analyses, we found no strong statistical evidence for an association between maternal alcohol consumption and facial phenotypes tested. The directions of effect estimates were compatible with the known effects of heavy alcohol exposure, but confidence intervals were largely centered around zero. There is no strong evidence, in a sample representative of the general population, for an effect of prenatal alcohol exposure on normal-range variation in facial morphology.
Sections du résumé
BACKGROUND
High levels of prenatal alcohol exposure are known to cause an array of adverse outcomes including fetal alcohol syndrome (FAS); however, the effects of low to moderate exposure are less-well characterized. Previous findings suggest that differences in normal-range facial morphology may be a marker for alcohol exposure and related adverse effects.
METHODS
In the Avon Longitudinal Study of Parents and Children, we tested for an association between maternal alcohol consumption and six FAS-related facial phenotypes in their offspring, using both self-report questionnaires and the maternal genotype at rs1229984 in ADH1B as measures of maternal alcohol consumption.
RESULTS
In both self-reported alcohol consumption (N = 4233) and rs1229984 genotype (N = 3139) analyses, we found no strong statistical evidence for an association between maternal alcohol consumption and facial phenotypes tested. The directions of effect estimates were compatible with the known effects of heavy alcohol exposure, but confidence intervals were largely centered around zero.
CONCLUSIONS
There is no strong evidence, in a sample representative of the general population, for an effect of prenatal alcohol exposure on normal-range variation in facial morphology.
Identifiants
pubmed: 30772781
pii: S0376-8716(19)30041-9
doi: 10.1016/j.drugalcdep.2018.11.031
pii:
doi:
Substances chimiques
Biomarkers
0
ADH1B protein, human
EC 1.1.1.1
Alcohol Dehydrogenase
EC 1.1.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
42-47Subventions
Organisme : Medical Research Council
ID : G0902144
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 208806/Z/17/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102215/2/13/2
Pays : United Kingdom
Informations de copyright
Copyright © 2019. Published by Elsevier B.V.