VaccHemInf project: protocol for a prospective cohort study of efficacy, safety and characterisation of immune functional response to vaccinations in haematopoietic stem cell transplant recipients.
Antibodies, Bacterial
/ blood
Antibodies, Viral
/ blood
Diphtheria Toxin
/ immunology
Flow Cytometry
France
Graft vs Host Disease
/ immunology
Haemophilus influenzae type b
/ immunology
Hematopoietic Stem Cell Transplantation
Hepatitis B virus
/ immunology
Humans
Longitudinal Studies
Postoperative Care
Prospective Studies
Streptococcus pneumoniae
/ immunology
Tetanus Toxin
/ immunology
Transplantation Immunology
Vaccination
Vaccines
/ immunology
allogeneic haematopoietic stem cell transplantation
autologous haematopoietic stem cell transplantation
chronic graft-versus-host disease
haematopoietic stem cell transplantation
immune functional assay
vaccination
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
entrez:
18
2
2019
pubmed:
18
2
2019
medline:
26
3
2020
Statut:
epublish
Résumé
Immune reconstitution after haematopoietic stem cell transplantation (HSCT) is a complex and dynamic process, varying from a state of nearly complete immunosuppression to an expected full immune recovery. Specific vaccination guidelines recommend reimmunisation after HSCT but data regarding vaccine efficacy in this unique population are scarce. New immune functional assays could enable prediction of vaccine response in the setting of HSCT. A prospective, longitudinal single-centre cohort study of autologous and allogeneic HSCT recipients was designed in order to determine the vaccine response to five vaccine targets (pneumococcus, hepatitis B virus, Ethical approval has been obtained from the institutional review board (no 69HCL17_0769). Results will be communicated at scientific meetings and submitted for publication in peer-reviewed journals. NCT03659773; Pre-results.
Identifiants
pubmed: 30772864
pii: bmjopen-2018-026093
doi: 10.1136/bmjopen-2018-026093
pmc: PMC6398679
doi:
Substances chimiques
Antibodies, Bacterial
0
Antibodies, Viral
0
Diphtheria Toxin
0
Tetanus Toxin
0
Vaccines
0
Banques de données
ClinicalTrials.gov
['NCT03659773']
Types de publication
Clinical Trial Protocol
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e026093Investigateurs
F Ader
(F)
V Alcazer
(V)
E Bachy
(E)
M Balsat
(M)
F Barraco
(F)
M Boccard
(M)
J S Casalegno
(JS)
C Chidiac
(C)
A Conrad
(A)
S Ducastelle-Leprêtre
(S)
O Dumitrescu
(O)
D Dupont
(D)
V Escuret
(V)
T Ferry
(T)
G Fossard
(G)
E Frobert
(E)
S Goutelle
(S)
E Hodille
(E)
H Labussière-Wallet
(H)
M-V Larcher
(MV)
F Laurent
(F)
B Lina
(B)
G Lina
(G)
J Menotti
(J)
B Meunier
(B)
P Miailhes
(P)
G Monneret
(G)
F Morfin-Sherpa
(F)
E Paubelle
(E)
T Perpoint
(T)
M Rabodonirina
(M)
C Roure-Sobas
(C)
G Salles
(G)
X Thomas
(X)
S Trouillet-Assant
(S)
F Valour
(F)
F Wallet
(F)
M Wallon
(M)
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: KB-P is an employee of bioMérieux SA, an in vitro diagnostic company.
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