HO-1 concentrations 24 hours after cardiac surgery are associated with the incidence of acute kidney injury: a prospective cohort study.
acute kidney injury
cardiac surgery
cardiopulmonary bypass
heme oxygenase-1
Journal
International journal of nephrology and renovascular disease
ISSN: 1178-7058
Titre abrégé: Int J Nephrol Renovasc Dis
Pays: New Zealand
ID NLM: 101550217
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
19
2
2019
pubmed:
19
2
2019
medline:
19
2
2019
Statut:
epublish
Résumé
Acute kidney injury (AKI) is a serious complication after cardiac surgery that is associated with increased mortality and morbidity. Heme oxygenase-1 (HO-1) is an enzyme synthesized in renal tubular cells as one of the most intense responses to oxidant stress linked with protective, anti-inflammatory properties. Yet, it is unknown if serum HO-1 induction following cardiac surgical procedure involving cardiopulmonary bypass (CPB) is associated with incidence and severity of AKI. In the present study, we used data from a prospective cohort study of 150 adult cardiac surgical patients. HO-1 measurements were performed before, immediately after and 24 hours post-CPB. In univariate and multivariate analyses, the association between HO-1 and AKI was investigated. AKI with an incidence of 23.3% (35 patients) was not associated with an early elevation of HO-1 after CPB in all patients ( The association of the second HO-1 burst 24 hours after CBP might help to distinguish between the causality of AKI in patients undergoing CBP, thus helping to adapt patient stratification and management.
Sections du résumé
BACKGROUND
BACKGROUND
Acute kidney injury (AKI) is a serious complication after cardiac surgery that is associated with increased mortality and morbidity. Heme oxygenase-1 (HO-1) is an enzyme synthesized in renal tubular cells as one of the most intense responses to oxidant stress linked with protective, anti-inflammatory properties. Yet, it is unknown if serum HO-1 induction following cardiac surgical procedure involving cardiopulmonary bypass (CPB) is associated with incidence and severity of AKI.
PATIENTS AND METHODS
METHODS
In the present study, we used data from a prospective cohort study of 150 adult cardiac surgical patients. HO-1 measurements were performed before, immediately after and 24 hours post-CPB. In univariate and multivariate analyses, the association between HO-1 and AKI was investigated.
RESULTS
RESULTS
AKI with an incidence of 23.3% (35 patients) was not associated with an early elevation of HO-1 after CPB in all patients (
CONCLUSION
CONCLUSIONS
The association of the second HO-1 burst 24 hours after CBP might help to distinguish between the causality of AKI in patients undergoing CBP, thus helping to adapt patient stratification and management.
Identifiants
pubmed: 30774413
doi: 10.2147/IJNRD.S165308
pii: ijnrd-12-009
pmc: PMC6350641
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9-18Déclaration de conflit d'intérêts
Disclosure The authors report no conflicts of interest in this work.
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