The Immunology of Macrophage Activation Syndrome.
IL-1
IL-18
IL-6
NK cell
anakinra
cytokine storm
hemophagocytic lymphohistiocytosis
macrophage activation syndrome
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
10
2018
accepted:
15
01
2019
entrez:
19
2
2019
pubmed:
19
2
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Synonymous with secondary hemophagocytic lymphohistiocytosis, macrophage activation syndrome (MAS) is a term used by rheumatologists to describe a potentially life-threatening complication of systemic inflammatory disorders, most commonly systemic juvenile idiopathic arthritis (sJIA) and systemic lupus erythematosus (SLE). Clinical and laboratory features of MAS include sustained fever, hyperferritinemia, pancytopenia, fibrinolytic coagulopathy, and liver dysfunction. Soluble interleukin-2 receptor alpha chain (sCD25) and sCD163 may be elevated, and histopathology often reveals characteristic increased hemophagocytic activity in the bone marrow (and other tissues), with positive CD163 (histiocyte) staining. A common hypothesis as to the pathophysiology of many cases of MAS proposes a defect in lymphocyte cytolytic activity. Specific heterozygous gene mutations in familial HLH-associated cytolytic pathway genes (e.g.,
Identifiants
pubmed: 30774631
doi: 10.3389/fimmu.2019.00119
pmc: PMC6367262
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
119Subventions
Organisme : NIAMS NIH HHS
ID : T32 AR069516
Pays : United States
Références
Eur J Immunol. 2000 Oct;30(10):3057-60
pubmed: 11069090
Case Rep Rheumatol. 2017;2017:5304180
pubmed: 29209549
PLoS One. 2011;6(5):e20014
pubmed: 21637346
J Pediatr. 1996 Feb;128(2):275-8
pubmed: 8636829
Curr Rheumatol Rep. 2014;16(9):439
pubmed: 25086802
Arthritis Rheum. 2008 Sep;58(9):2892-6
pubmed: 18759271
Clin Rheumatol. 2015 Aug;34(8):1333-9
pubmed: 25846831
Cell. 2003 Nov 14;115(4):461-73
pubmed: 14622600
Arthritis Rheumatol. 2018 Apr;70(4):616-624
pubmed: 29342508
Curr Opin Rheumatol. 2014 Sep;26(5):562-9
pubmed: 25022357
Arthritis Rheum. 2007 Nov;56(11):3793-804
pubmed: 17968951
Blood. 2018 Mar 29;131(13):1430-1441
pubmed: 29295842
Arthritis Rheum. 2011 Feb;63(2):545-55
pubmed: 21280009
Arthritis Rheumatol. 2018 Jun;70(6):963-970
pubmed: 29409136
Immunol Rev. 2018 Jan;281(1):138-153
pubmed: 29247988
Acta Haematol. 2012;128(2):69-72
pubmed: 22678422
J Exp Med. 2005 May 2;201(9):1479-86
pubmed: 15851489
Blood. 2005 Feb 15;105(4):1648-51
pubmed: 15466922
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8798-803
pubmed: 11447290
Isr Med Assoc J. 2010 Jul;12(7):443-5
pubmed: 20862830
Blood. 2002 Jan 1;99(1):378-80
pubmed: 11756196
N Engl J Med. 2014 Oct 16;371(16):1507-17
pubmed: 25317870
Rheumatology (Oxford). 2010 Mar;49(3):441-9
pubmed: 20019066
Blood. 2015 Mar 5;125(10):1566-77
pubmed: 25564401
Immunity. 2010 Jun 25;32(6):790-802
pubmed: 20605485
Blood. 2016 Mar 31;127(13):1666-75
pubmed: 26825707
J Clin Invest. 2009 Dec;119(12):3765-73
pubmed: 19884660
J Rheumatol. 2013 Jun;40(6):761-7
pubmed: 23588947
Ann Clin Lab Sci. 2012 Winter;42(1):21-5
pubmed: 22371906
Circ Res. 2006 Oct 27;99(9):943-50
pubmed: 17008602
Arthritis Rheumatol. 2014 Dec;66(12):3486-95
pubmed: 25047945
Blood. 2006 Jul 1;108(1):81-7
pubmed: 16551969
Cytokine. 2018 Oct;110:459-465
pubmed: 29801971
J Exp Med. 2014 Jun 2;211(6):1079-91
pubmed: 24842371
J Exp Med. 2011 Jun 6;208(6):1203-14
pubmed: 21624938
Rheumatology (Oxford). 2011 Feb;50(2):417-9
pubmed: 20693540
J Pediatr. 2005 May;146(5):598-604
pubmed: 15870661
Arthritis Care Res (Hoboken). 2018 Mar;70(3):409-419
pubmed: 28499329
Arthritis Rheum. 2007 Mar;56(3):965-71
pubmed: 17328073
Immunol Rev. 2018 Jan;281(1):8-27
pubmed: 29247995
Pediatr Blood Cancer. 2007 Feb;48(2):124-31
pubmed: 16937360
J Immunol. 2000 Mar 15;164(6):3095-101
pubmed: 10706699
Blood. 2003 Jan 15;101(2):594-601
pubmed: 12393630
Curr Allergy Asthma Rep. 2013 Aug;13(4):337-46
pubmed: 23605168
Clin Rheumatol. 2018 Dec;37(12):3329-3335
pubmed: 29663156
Cell Rep. 2015 Sep 22;12(11):1902-14
pubmed: 26365184
Annu Rev Physiol. 2017 Feb 10;79:541-566
pubmed: 27813830
Front Pharmacol. 2014 Apr 17;5:79
pubmed: 24860503
Nat Rev Rheumatol. 2016 May;12(5):259-68
pubmed: 27009539
J Rheumatol. 2007 May;34(5):1133-8
pubmed: 17343315
Blood. 2010 Oct 7;116(14):2476-83
pubmed: 20570861
J Immunol. 2015 Jun 1;194(11):5041-3
pubmed: 25980027
Curr Rheumatol Rep. 2016 Jul;18(7):45
pubmed: 27306623
Pflugers Arch. 2017 Apr;469(3-4):365-374
pubmed: 28185068
J Pediatr Hematol Oncol. 2017 Aug;39(6):445-451
pubmed: 28562511
J Pediatr. 1985 Apr;106(4):561-6
pubmed: 3981309
Immunity. 1997 Dec;7(6):837-47
pubmed: 9430229
Arthritis Rheum. 1991 Sep;34(9):1158-63
pubmed: 1930333
J Clin Invest. 2011 Jun;121(6):2264-77
pubmed: 21576823
Science. 1999 Dec 3;286(5446):1957-9
pubmed: 10583959
J Allergy Clin Immunol. 2018 Apr;141(4):1439-1449
pubmed: 28807602
Eur J Haematol. 2005 Jan;74(1):6-10
pubmed: 15613100
J Leukoc Biol. 2018 Jan;103(1):71-85
pubmed: 29345059
J Allergy Clin Immunol. 2015 Jun;135(6):1638-41
pubmed: 25592983
Virol J. 2017 Dec 19;14(1):240
pubmed: 29258535
Front Immunol. 2018 Sep 24;9:2162
pubmed: 30319625
J Exp Med. 1998 Jun 1;187(11):1903-20
pubmed: 9607930
Arthritis Rheum. 2012 May;64(5):1680-8
pubmed: 22108837
Adv Exp Med Biol. 2007;601:225-33
pubmed: 17713009
Biochem Biophys Res Commun. 1999 Mar 5;256(1):110-3
pubmed: 10066432
J Rheumatol. 2017 Jul;44(7):970-972
pubmed: 28668814
Rheumatol Int. 2013 Apr;33(4):1097-8
pubmed: 22193231
Ann Rheum Dis. 2016 Mar;75(3):481-9
pubmed: 26865703
Arthritis Rheum. 2008 Feb;58(2):567-70
pubmed: 18240215
Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):147-52
pubmed: 16373503
Hum Mol Genet. 2005 Mar 15;14(6):827-34
pubmed: 15703195
Immunity. 2014 Jul 17;41(1):14-20
pubmed: 25035950
Blood. 2011 Jun 16;117(24):6582-8
pubmed: 21551232
Arthritis Res Ther. 2005;7(1):R30-7
pubmed: 15642140
Immunity. 2014 Feb 20;40(2):274-88
pubmed: 24530056
J Allergy Clin Immunol. 2017 May;139(5):1698-1701
pubmed: 27876626
Clin Exp Immunol. 2018 Mar;191(3):349-355
pubmed: 28815559
N Engl J Med. 2012 Dec 20;367(25):2385-95
pubmed: 23252525
Rheumatol Int. 2019 Jan;39(1):97-104
pubmed: 30051293
Blood. 2013 Jun 27;121(26):5184-91
pubmed: 23660960
Rheumatology (Oxford). 2005 Nov;44(11):1350-3
pubmed: 15956091
Am J Clin Pathol. 2014 Jan;141(1):62-71
pubmed: 24343738
Science. 1997 Nov 28;278(5343):1612-5
pubmed: 9374458
Arthritis Rheumatol. 2016 Mar;68(3):566-76
pubmed: 26314788
J Pediatr. 2006 May;148(5):683-6
pubmed: 16737887
Pediatr Rheumatol Online J. 2014 Apr 23;12:13
pubmed: 24782683
Blood. 2016 Jan 28;127(4):426-35
pubmed: 26518437
J Pediatr. 1996 Nov;129(5):750-4
pubmed: 8917244
Hematol Oncol Clin North Am. 2015 Oct;29(5):895-902
pubmed: 26461149
Blood. 2004 Aug 1;104(3):735-43
pubmed: 15069016
Cancer. 1985 Aug 1;56(3):524-30
pubmed: 2988747
Rheumatology (Oxford). 2010 Sep;49(9):1645-53
pubmed: 20472718
Curr Opin Immunol. 2017 Dec;49:20-26
pubmed: 28866302
J Rheumatol. 2011 Jan;38(1):180-1
pubmed: 21196588
J Rheumatol. 2015 Apr;42(4):712-22
pubmed: 25684767
Blood. 1990 Dec 15;76(12):2466-9
pubmed: 2265243
J Rheumatol. 2015 Jun;42(6):994-1001
pubmed: 25877504
Blood. 2011 Jul 21;118(3):618-26
pubmed: 21606480
Clin Exp Rheumatol. 2002 Mar-Apr;20(2):121-3
pubmed: 12051388
Pediatr Crit Care Med. 2014 Jun;15(5):401-8
pubmed: 24583503
Immunol Rev. 2018 Jan;281(1):115-123
pubmed: 29247997
Am J Clin Pathol. 2004 Nov;122(5):794-801
pubmed: 15491976
J Pediatr. 2003 Mar;142(3):292-6
pubmed: 12640378
J Immunol. 2016 Mar 15;196(6):2492-503
pubmed: 26880764
J Exp Med. 1983 Sep 1;158(3):670-89
pubmed: 6411853
J Leukoc Biol. 2004 Sep;76(3):509-13
pubmed: 15218057
J Pediatr. 2012 Jun;160(6):984-90.e1
pubmed: 22226576
Autoimmun Rev. 2008 Feb;7(4):305-8
pubmed: 18295734
Arthritis Rheum. 2013 Jul;65(7):1764-75
pubmed: 23553372
J Infect Dis. 2016 Apr 1;213(7):1180-8
pubmed: 26597256
Int Immunol. 2018 Apr 25;30(5):195-203
pubmed: 29420734
Expert Rev Clin Immunol. 2015;11(9):1043-53
pubmed: 26082353
Mol Cell. 1998 Aug;2(2):253-8
pubmed: 9734363
Annu Rev Immunol. 2012;30:1-22
pubmed: 22136168
J Exp Med. 2015 Mar 9;212(3):307-17
pubmed: 25732304
Proteomics. 2010 Dec;10(24):4415-30
pubmed: 21136595
Nat Genet. 2000 Jun;25(2):173-6
pubmed: 10835631
Nat Med. 2018 Jun;24(6):739-748
pubmed: 29808007
Nature. 2001 Jan 11;409(6817):198-201
pubmed: 11196644
Blood. 2018 Mar 29;131(13):1442-1455
pubmed: 29326099
Trends Immunol. 2003 Aug;24(8):449-55
pubmed: 12909459
Pediatr Clin North Am. 2012 Apr;59(2):329-44
pubmed: 22560573
Rheumatology (Oxford). 2001 Nov;40(11):1285-92
pubmed: 11709613