Hide and Seek: Nanomaterial Interactions With the Immune System.

bio-corona biomimetic immune system nanomaterials stealth targeting

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2019
Historique:
received: 02 11 2018
accepted: 16 01 2019
entrez: 19 2 2019
pubmed: 19 2 2019
medline: 7 1 2020
Statut: epublish

Résumé

Engineered nanomaterials hold promise for a wide range of applications in medicine. However, safe use of nanomaterials requires that interactions with biological systems, not least with the immune system, are understood. Do nanomaterials elicit novel or unexpected effects, or is it possible to predict immune responses to nanomaterials based on how the immune system handles pathogens? How does the bio-corona of adsorbed biomolecules influence subsequent immune interactions of nanomaterials? How does the grafting of polymers such as poly(ethylene glycol) onto nanomaterial surfaces impact on these interactions? Can ancient immune evasion or "stealth" strategies of pathogens inform the design of nanomaterials for biomedical applications? Can nanoparticles co-opt immune cells to target diseased tissues? The answers to these questions may prove useful for the development of nanomedicines.

Identifiants

pubmed: 30774634
doi: 10.3389/fimmu.2019.00133
pmc: PMC6367956
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

133

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Auteurs

Bengt Fadeel (B)

Nanosafety and Nanomedicine Laboratory, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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Classifications MeSH