Application of Proteomics to Inflammatory Bowel Disease Research: Current Status and Future Perspectives.
Journal
Gastroenterology research and practice
ISSN: 1687-6121
Titre abrégé: Gastroenterol Res Pract
Pays: Egypt
ID NLM: 101475557
Informations de publication
Date de publication:
2019
2019
Historique:
received:
17
07
2018
accepted:
08
10
2018
entrez:
19
2
2019
pubmed:
19
2
2019
medline:
19
2
2019
Statut:
epublish
Résumé
Inflammatory bowel disease (IBD) is a chronic relapsing/remitting inflammatory illness of the gastrointestinal tract of unknown aetiology. Despite recent advances in decoding the pathophysiology of IBD, many questions regarding disease pathogenesis remain. Genome-wide association studies (GWAS) and knockout mouse models have significantly advanced our understanding of genetic susceptibility loci and inflammatory pathways involved in IBD pathogenesis. Despite their important contribution to a better delineation of the disease process in IBD, these genetic findings have had little clinical impact to date. This is because the presence of a given gene mutation does not automatically correspond to changes in its expression or final metabolic or structural effect(s). Furthermore, the existence of these gene susceptibility loci in the normal population suggests other driving prerequisites for the disease manifestation. Proteins can be considered the main functional units as almost all intracellular physiological functions as well as intercellular interactions are dependent on them. Proteomics provides methods for the large-scale study of the proteins encoded by the genome of an organism or a cell, to directly investigate the proteins and pathways involved. Understanding the proteome composition and alterations yields insights into IBD pathogenesis as well as identifying potential biomarkers of disease activity, mucosal healing, and cancer progression. This review describes the state of the art in the field with respect to the study of IBD and the potential for translation from biomarker discovery to clinical application.
Identifiants
pubmed: 30774653
doi: 10.1155/2019/1426954
pmc: PMC6350533
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1426954Références
Inflamm Bowel Dis. 2017 Jan;23(1):2-13
pubmed: 27779499
Inflamm Bowel Dis. 2007 Apr;13(4):481-9
pubmed: 17206705
Mol Med Rep. 2008 Jan-Feb;1(1):51-4
pubmed: 21479377
Expert Rev Mol Diagn. 2017 Sep;17(9):835-843
pubmed: 28770636
Immunol Rev. 2005 Aug;206:296-305
pubmed: 16048556
Inflamm Bowel Dis. 2012 Jun;18(6):999-1005
pubmed: 21688352
Proteomics. 2002 May;2(5):551-60
pubmed: 11987129
World J Gastroenterol. 2014 Jan 7;20(1):6-21
pubmed: 24415853
World J Gastroenterol. 2014 Jan 7;20(1):64-77
pubmed: 24415859
Proteomics. 2006 Apr;6 Suppl 1:S282-92
pubmed: 16544281
J Crohns Colitis. 2013 Nov;7(10):e461-70
pubmed: 23562004
J Dig Dis. 2013 Apr;14(4):166-74
pubmed: 23320753
Nat Rev Mol Cell Biol. 2003 Jan;4(1):74-80
pubmed: 12511871
Curr Opin Gastroenterol. 2015 Jan;31(1):81-8
pubmed: 25426970
Nitric Oxide. 2008 Sep;19(2):65-7
pubmed: 18638716
Inflamm Bowel Dis. 2018 Jul 12;24(8):1619-1623
pubmed: 29846593
Tissue Barriers. 2013 Dec 1;1(5):e27321
pubmed: 24868498
Shock. 1999 Jan;11(1):1-12
pubmed: 9921710
Br J Cancer. 2009 Aug 4;101(3):492-7
pubmed: 19603022
Biochem Pharmacol. 2007 May 1;73(9):1422-33
pubmed: 17258689
Scand J Gastroenterol. 1985 Mar;20(2):209-14
pubmed: 3992179
FASEB J. 2004 Oct;18(13):1550-2
pubmed: 15289440
Electrophoresis. 1997 Dec;18(14):2582-90
pubmed: 9527488
BMC Gastroenterol. 2012 Jun 24;12:76
pubmed: 22726388
Hum Mutat. 2009 Jan;30(1):56-60
pubmed: 18666241
Nat Rev Genet. 2013 Jan;14(1):35-48
pubmed: 23207911
Clin Pharmacol Ther. 2001 Mar;69(3):89-95
pubmed: 11240971
Nat Cell Biol. 2005 Sep;7(9):909-15
pubmed: 16113678
Biochim Biophys Acta. 2014 Jan;1843(1):86-96
pubmed: 23872423
J Proteome Res. 2011 Jan 7;10(1):200-9
pubmed: 20828217
Gastroenterology. 2004 May;126(6):1504-17
pubmed: 15168363
Dig Dis Sci. 2008 Jan;53(1):242-7
pubmed: 17549633
Immunity. 2006 Aug;25(2):309-18
pubmed: 16919486
J Clin Invest. 2011 Oct;121(10):4170-9
pubmed: 21946256
PPAR Res. 2009;2009:830501
pubmed: 19609453
Am J Gastroenterol. 2008 Mar;103(3):643-8
pubmed: 18341488
Proteomics. 2017 Jan;17(1-2):
pubmed: 27775219
Eur J Appl Physiol. 2009 Jul;106(4):639-44
pubmed: 19347351
J Proteomics. 2009 Jul 21;72(5):865-73
pubmed: 19168159
Gastroenterology. 2007 Dec;133(6):1893-904
pubmed: 18054561
J Biol Chem. 2014 Jan 17;289(3):1429-40
pubmed: 24240172
PLoS One. 2011 Feb 18;6(2):e17213
pubmed: 21365000
Proteomics Clin Appl. 2015 Apr;9(3-4):295-300
pubmed: 25504339
J Biol Chem. 1995 Sep 15;270(37):21707-14
pubmed: 7665588
J Transl Med. 2013 Oct 10;11:253
pubmed: 24107468
Nat Genet. 2011 Mar;43(3):246-52
pubmed: 21297633
Ann Intern Med. 2012 Mar 6;156(5):350-9
pubmed: 22393130
Expert Rev Proteomics. 2016 Oct;13(10):901-903
pubmed: 27568488
Int Immunopharmacol. 2010 Oct;10(10):1261-7
pubmed: 20650341
Biochim Biophys Acta. 2013 Aug;1834(8):1581-90
pubmed: 23567906
Chem Biol Interact. 2014 May 25;215:7-16
pubmed: 24631021
Cancer Res. 2006 Jul 1;66(13):6553-62
pubmed: 16818627
J Proteome Res. 2007 Mar;6(3):1114-25
pubmed: 17330946
J Proteomics. 2018 Mar 20;175:12-26
pubmed: 28855124
Lancet. 2007 May 12;369(9573):1627-40
pubmed: 17499605
Mol Cell Proteomics. 2018 Nov;17(11):2284-2296
pubmed: 30104208
FEBS J. 2015 Feb;282(3):435-44
pubmed: 25354325
Proteomics. 2018 Jul;18(14):e1700463
pubmed: 29785737
Clin Transl Sci. 2018 Jan;11(1):4-7
pubmed: 28986961
Gut. 2010 May;59(5):595-604
pubmed: 20427394
Mol Omics. 2019 Feb 11;15(1):67-76
pubmed: 30702115
Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):39-49
pubmed: 29018271
J Biol Chem. 1993 Feb 5;268(4):2793-801
pubmed: 8428953
Mol Cell Proteomics. 2017 Apr;16(4):694-705
pubmed: 28126900
Prog Lipid Res. 2006 Mar;45(2):120-59
pubmed: 16476485
Pathol Int. 2009 Oct;59(10):701-11
pubmed: 19788615
Cell Mol Life Sci. 2015 Apr;72(8):1447-62
pubmed: 25537302
Proteomics Clin Appl. 2009 Sep 14;3(11):1326
pubmed: 20098637
Inflamm Res. 2007 Sep;56(9):377-84
pubmed: 17879000
J Exp Med. 1988 Dec 1;168(6):2295-308
pubmed: 3199069
Inflamm Bowel Dis. 2009 Apr;15(4):616-29
pubmed: 18844215
Nature. 2010 Mar 4;464(7285):59-65
pubmed: 20203603
Nat Rev Immunol. 2014 May;14(5):329-42
pubmed: 24751956
Histol Histopathol. 1999 Oct;14(4):1199-212
pubmed: 10506936
Dig Dis Sci. 1998 May;43(5):1079-87
pubmed: 9590425
Anal Chem. 2004 Feb 15;76(4):1145-55
pubmed: 14961749
J Cell Biochem. 1996 Jun 15;61(4):531-42
pubmed: 8806076
Dig Dis Sci. 2012 Nov;57(11):2755-64
pubmed: 22740064
Nat Rev Gastroenterol Hepatol. 2016 Jan;13(1):13-27
pubmed: 26627550
Gen Physiol Biophys. 1998 Sep;17(3):193-210
pubmed: 9834842
Rapid Commun Mass Spectrom. 2006;20(13):1989-94
pubmed: 16755610
Am J Gastroenterol. 2010 Nov;105(11):2412-9
pubmed: 20588264
Aliment Pharmacol Ther. 2000 Dec;14(12):1553-9
pubmed: 11121902
Bioanalysis. 2018 Sep 1;10(17):1383-1399
pubmed: 30207162
J Proteomics. 2019 Jan 16;191:22-28
pubmed: 29777872
Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):290-5
pubmed: 21173247
Proteomics Clin Appl. 2013 Aug;7(7-8):541-9
pubmed: 23382084
Curr Protein Pept Sci. 2004 Apr;5(2):89-105
pubmed: 15078220
Expert Rev Proteomics. 2015 Feb;12(1):13-9
pubmed: 25404501
Clin Gastroenterol Hepatol. 2007 Dec;5(12):1430-8
pubmed: 18054751
Sci Rep. 2018 May 18;8(1):7834
pubmed: 29777136
Am J Gastroenterol. 2018 May;113(5):713-724
pubmed: 29531307
Mol Cell Proteomics. 2012 Jun;11(6):O111.016717
pubmed: 22261725
Immunol Rev. 2004 Dec;202:96-105
pubmed: 15546388
Korean J Physiol Pharmacol. 2012 Jun;16(3):193-8
pubmed: 22802701
BMJ Open Gastroenterol. 2015 May 18;2(1):e000024
pubmed: 26462276
Clin Chem. 1996 Oct;42(10):1589-600
pubmed: 8855140
Mol Cell Proteomics. 2018 Dec;17(12):2534-2545
pubmed: 30385480
Am J Clin Nutr. 2004 Nov;80(5):1342-52
pubmed: 15531685
J Gastroenterol. 2010 May;45(5):488-500
pubmed: 20049485
Anal Chem. 2018 Jan 2;90(1):86-109
pubmed: 29061041
FEBS Lett. 2014 Apr 17;588(8):1430-8
pubmed: 24440348
Clin Biochem. 2008 Aug;41(12):960-7
pubmed: 18489908
J Pediatr Gastroenterol Nutr. 1996 Aug;23(2):164-71
pubmed: 8856584
Circulation. 2009 Aug 4;120(5):427-36
pubmed: 19620505
Inflamm Bowel Dis. 2015 Sep;21(9):2052-67
pubmed: 25993694
Curr Opin Gastroenterol. 2013 Mar;29(2):146-52
pubmed: 23283180
J Biol Chem. 2015 Jan 2;290(1):577-89
pubmed: 25398881
Eur J Surg Oncol. 2008 Apr;34(4):357-64
pubmed: 17566693
Pathol Res Pract. 2004;200(2):69-82
pubmed: 15237916
Front Immunol. 2017 Feb 06;8:81
pubmed: 28220120
J Immunol. 2002 May 15;168(10):5342-51
pubmed: 11994493
Pathol Int. 2005 Mar;55(3):113-21
pubmed: 15743319
BMJ. 2013 Nov 14;347:f6633
pubmed: 24231178
Antioxid Redox Signal. 2010 Feb;12(2):293-304
pubmed: 19659435
J Nutr Biochem. 2013 Oct;24(10):1678-90
pubmed: 23643524
Annu Rev Med. 2002;53:409-35
pubmed: 11818483
J Cell Biol. 2001 Oct 29;155(3):415-26
pubmed: 11684708
Nan Fang Yi Ke Da Xue Xue Bao. 2012 Nov;32(11):1548-52
pubmed: 23174572
Nat Med. 2007 Sep;13(9):1042-9
pubmed: 17767165
Biochimie. 2002 Dec;84(12):1207-20
pubmed: 12628297
Dig Dis Sci. 1996 Oct;41(10):2078-86
pubmed: 8888724
Cancer Lett. 2009 Jun 28;279(1):39-46
pubmed: 19217207
Gastroenterol Clin North Am. 1999 Jun;28(2):255-81, vii
pubmed: 10372268
Proteomics. 2005 Aug;5(13):3226-45
pubmed: 16104056
J Proteomics. 2015 Jan 01;112:166-79
pubmed: 25230104
Gastroenterology. 2013 Feb;144(2):283-293
pubmed: 23219999
PLoS One. 2013 Jul 03;8(7):e67145
pubmed: 23843990
Proteomics. 2006 Oct;6(19):5322-31
pubmed: 16947118
Inflamm Bowel Dis. 2005 Oct;11(10):927-36
pubmed: 16189423
Clin Chem. 2008 Mar;54(3):534-41
pubmed: 18218721
Mol Cell Proteomics. 2004 Dec;3(12):1154-69
pubmed: 15385600
Int J Immunopathol Pharmacol. 2008 Apr-Jun;21(2):289-95
pubmed: 18547472
Gastroenterology. 2014 Apr;146(4):1028-39
pubmed: 24417819
Shock. 2009 Mar;31(3):308-16
pubmed: 18665053
Expert Rev Gastroenterol Hepatol. 2012 Apr;6(2):223-37
pubmed: 22375527
Electrophoresis. 2000 Nov;21(17):3673-83
pubmed: 11271486
J Cell Physiol. 2014 Aug;229(8):998-1004
pubmed: 24347342
Inflamm Bowel Dis. 2018 Sep 15;24(10):2113-2122
pubmed: 29718255
Mass Spectrom Rev. 2018 Sep;37(5):583-606
pubmed: 29120501
Proteomics. 2017 Feb;17(3-4):
pubmed: 28127880
Nat Methods. 2018 Jun;15(6):440-448
pubmed: 29735998
Am J Pathol. 2009 Jul;175(1):207-14
pubmed: 19528350
Mol Cell Proteomics. 2002 May;1(5):376-86
pubmed: 12118079
Sensors (Basel). 2018 Jun 14;18(6):
pubmed: 29899214
Circ Res. 2003 May 16;92(9):962-8
pubmed: 12750306
Lancet. 1994 Mar 26;343(8900):766-7
pubmed: 7907734
Biochem Med (Zagreb). 2014 Feb 15;24(1):31-44
pubmed: 24627713
Eur J Gastroenterol Hepatol. 2001 Dec;13(12):1415-9
pubmed: 11742189
J Exp Med. 1999 May 3;189(9):1363-72
pubmed: 10224276
Gut. 2011 May;60(5):631-7
pubmed: 21209126
Cytokine. 2004 Nov 21-Dec 7;28(4-5):167-73
pubmed: 15588691
Gut. 2017 Feb;66(2):362-381
pubmed: 27802156
Dis Colon Rectum. 2007 Aug;50(8):1230-40
pubmed: 17587138
Mol Cell Proteomics. 2014 Sep;13(9):2513-26
pubmed: 24942700
Lancet. 1980 Oct 4;2(8197):712-5
pubmed: 6106826
Microbiome. 2016 Jun 24;4(1):31
pubmed: 27343061
New Biol. 1990 Apr;2(4):313-23
pubmed: 2149646
Immunol Rev. 2005 Aug;206:277-95
pubmed: 16048555
Autoimmun Rev. 2014 Jan;13(1):3-10
pubmed: 23774107
Gut. 2017 Sep;66(9):1573-1583
pubmed: 27216938
Gut. 2005 Oct;54(10):1481-91
pubmed: 16162953
J Exp Med. 1987 Nov 1;166(5):1471-83
pubmed: 2960770
Carcinogenesis. 2002 Jul;23(7):1139-48
pubmed: 12117771
J Pediatr Gastroenterol Nutr. 2015 Jan;60(1):42-7
pubmed: 25250685
J Cell Biol. 2000 Apr 3;149(1):17-22
pubmed: 10747083
J Cell Sci. 2005 May 1;118(Pt 9):1971-80
pubmed: 15840656
Nature. 2012 Jan 18;481(7382):511-5
pubmed: 22258505
Mol Cell Proteomics. 2016 Jan;15(1):256-65
pubmed: 26530476
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):3127-36
pubmed: 19683480
Nat Genet. 2010 Dec;42(12):1118-25
pubmed: 21102463
Talanta. 2018 Aug 1;185:213-220
pubmed: 29759191
Semin Thromb Hemost. 2013 Jun;39(4):338-46
pubmed: 23483454
Inflamm Bowel Dis. 2010 Jul;16(7):1239-46
pubmed: 20127998
Clin Exp Immunol. 1998 Apr;112(1):10-6
pubmed: 9566783
Science. 1998 Aug 21;281(5380):1191-3
pubmed: 9712583
Gut. 2006 Mar;55(3):426-31
pubmed: 16474109
J Biol Chem. 1998 Mar 6;273(10):5892-902
pubmed: 9488727
Mol Immunol. 1992 Apr;29(4):537-46
pubmed: 1565101
Nat Methods. 2013 Mar;10(3):186-7
pubmed: 23443629
Eur J Med Chem. 2013;70:613-22
pubmed: 24211637
Gastroenterology. 2018 Apr;154(5):1320-1333.e10
pubmed: 29309774
Gut. 2002 Sep;51(3):379-85
pubmed: 12171960
Dis Markers. 1987 Mar;5(1):1-11
pubmed: 2458880
Anal Chem. 2003 Apr 15;75(8):1895-904
pubmed: 12713048
Semin Thromb Hemost. 2004 Jun;30(3):379-85
pubmed: 15282661
Nat Commun. 2016 Nov 23;7:13419
pubmed: 27876802
Biochem J. 2005 Aug 15;390(Pt 1):1-9
pubmed: 16083425
J Lipid Res. 1998 Jan;39(1):103-13
pubmed: 9469590
Nat Commun. 2018 Jul 20;9(1):2873
pubmed: 30030445
Int J Biochem Cell Biol. 2005 Jun;37(6):1162-7
pubmed: 15778080
Inflamm Bowel Dis. 2011 Apr;17(4):875-83
pubmed: 20806340
Anal Chem. 2016 Jun 21;88(12):6120-5
pubmed: 27248155
Chem Rev. 2013 Apr 10;113(4):2343-94
pubmed: 23438204
Curr Gastroenterol Rep. 2014;16(7):396
pubmed: 25048010
PLoS One. 2013 Dec 16;8(12):e81662
pubmed: 24358121
Inflamm Bowel Dis. 2009 Jun;15(6):909-17
pubmed: 19107772
Cell Microbiol. 2007 May;9(5):1252-61
pubmed: 17223928
Oncogene. 2006 Jun 26;25(27):3810-7
pubmed: 16799622
J Proteome Res. 2011 May 6;10(5):2216-25
pubmed: 21428429
Electrophoresis. 1995 Jul;16(7):1090-4
pubmed: 7498152
J Biol Chem. 2000 Oct 6;275(40):31128-33
pubmed: 10913121
Int J Cell Biol. 2012;2012:935173
pubmed: 22194750
Pharmacol Rev. 2006 Dec;58(4):726-41
pubmed: 17132851
Am J Gastroenterol. 2008 Jun;103(6):1451-9
pubmed: 18422819
Int J Cancer. 2007 Jun 15;120(12):2590-9
pubmed: 17290393
Inflamm Bowel Dis. 2004 Nov;10(6):848-59
pubmed: 15626903