Can we predict long-term survival in resectable pancreatic ductal adenocarcinoma?
PDAC
cell-free DNA
ion torrent
nanostring
next-generation sequencing
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
22 Jan 2019
22 Jan 2019
Historique:
received:
02
12
2018
accepted:
12
12
2018
entrez:
19
2
2019
pubmed:
19
2
2019
medline:
19
2
2019
Statut:
epublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumour associated with poor 5-year survival. We aimed to determine factors which differentiate short and long-term survivors and identify a prognostic biomarker. Over a ten-year period, patients with resected PDAC who developed disease recurrence within 12 months (Group I) and those who had no disease recurrence for 24 months (Group II) were identified. Clinicopathological data was analysed. Ion Torrent high-throughput sequencing on DNA extracted from FFPE tumour samples was used to identify mutations. Additionally, peripheral blood samples were analysed for variants in cell-free DNA, circulating tumour cells (CTCs), and microRNAs. Multivariable analysis of clinicopathological factors showed that a positive medial resection margin was significantly associated with short disease-free survival ( Medial resection margin status and the frequency of
Identifiants
pubmed: 30774772
doi: 10.18632/oncotarget.26511
pii: 26511
pmc: PMC6366827
doi:
Types de publication
Journal Article
Langues
eng
Pagination
696-706Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST None.
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